HC-COVID

The proliferation of social media has promoted the spread of misinformation that raises many concerns in our society. This paper focuses on a critical problem of explainable COVID-19 misinformation detection that aims to accurately identify and explain misleading COVID-19 claims on social media. Motivated by the lack of COVID-19 relevant knowledge in existing solutions, we construct a novel crowdsource knowledge graph based approach to incorporate the COVID-19 knowledge facts by leveraging the collaborative efforts of expert and non-expert crowd workers. Two important challenges exist in developing our solution: i) how to effectively coordinate the crowd efforts from both expert and non-expert workers to generate the relevant knowledge facts for detecting COVID-19 misinformation; ii) How to leverage the knowledge facts from the constructed knowledge graph to accurately explain the detected COVID-19 misinformation. To address the above challenges, we develop HC-COVID, a hierarchical crowdsource knowledge graph based framework that explicitly models the COVID-19 knowledge facts contributed by crowd workers with different levels of expertise and accurately identifies the related knowledge facts to explain the detection results. We evaluate HC-COVID using two public real-world datasets on social media. Evaluation results demonstrate that HC-COVID significantly outperforms state-of-the-art baselines in terms of the detection accuracy of misleading COVID-19 claims and the quality of the explanations.

The reverse motion illusion in random dot motion displays and implications for understanding development

Across two independent developmental labs, we have been puzzled by the observation that a small proportion of our child and adult participants consistently report perceiving motion in the direction opposite to that presented in random dot motion displays, sometimes even when the motion is at 100% coherence. In this review, we first draw together existing reports of misperceptions of motion direction in random dot displays across observers in a small percentage of trials, before reporting evidence of consistent reverse motion perception in a minority of observers, including previously unreported observations from our own studies of visual development. We consider possible explanations for this reverse motion illusion, including motion induction, motion energy, correspondence noise and spatial undersampling. However, more work is required to understand the individual differences relating to this percept. We suggest that errors in perceived motion direction are likely to be more widespread than can be currently gleaned from the literature and explain why systematic study is needed, especially in children. Finally, we list some remaining open questions and call for collaborative efforts to document this phenomenon and stimulate future investigation.

21the Wheelchair Project Case Study: Leveraging Collaborative Efforts and Partnerships to Provide Assitive Devices for People Affected by Disability in Thailand and Southeast Asia

Many people affected by disability require assistive devices, particularly mobility aids, in order to live independently and fully integrate into their communities. Throughout the world, numerous methods have been implemented in facilitating the provision of these devices to people affected by disabilities. This case study intends use the Rajanagarindra Institute of Child Development Wheelchair Project, located in Chiang Mai, Thailand, to evaluate the viability and efficacy of mobility-provision programs which adapt wheelchairs and other assistive devices not originally intended for the end user. Programs which must “retro-adapt” equipment, like the Wheelchair Project, rely heavily on medical and mechanical expertise to identify the recipients’ needs and safely modify the device accordingly. By examining the distribution statistics from the Wheelchair Project over its 20 years of operation and the needs of the disability community reported by the National Statistics Office of Thailand alongside a cost-benefit analysis of the declared value provided versus operational cost, this case-study systematically details the scope and financial viability of this approach. While not without constraints, this model succeeds in effectively capitalizing on available resources (both in regard to physical equipment as well as professional expertise) to meet the needs of those affected by disabilities in Thailand and Southeast Asia. Although still limited in size and reach, the Wheelchair Project demonstrably shows its viability and the potential this approach presents given the right circumstances.

Evaluating Human Mutation Databases for 'Treatability' Using Personalized Antisense Oligonucleotides

Genome sequencing in the clinic often allows patients to receive a molecular diagnosis. However, variants are most often evaluated for pathogenicity, neglecting potential "treatability", and thus often yielding limited clinical benefit. Several collaborative efforts now aim to provide a therapy based upon the genetic variants, even if the drug will benefit only a single patient. Antisense oligonucleotide (ASO) therapies, among others, offer attractive "programmable" and relatively safe platforms for individualized therapy. The landscape of "ASO-treatable" variants is largely uncharted, with new developments emerging for loss-of-function (LOF), haploinsufficient, and gain-of-function (GOF) variants. ASOs can access the genome to target splice-gain variants, poison exons, untranslated/regulatory regions, and naturally-occurring antisense transcripts. Many of these approaches have yet to be proven clinically beneficial, and it is unclear if disease in some patients has progressed past the point where benefit could reasonably be expected. Here we mine public variant databases to identify potential future therapeutic targets. We found that the majority of human pathogenic genetic variants have one or more approaches that could be targeted therapeutically, advantaging the many ways that ASOs can regulate gene expression. The future might see medical teams considering "treatability" when interpreting genome sequencing results, to fully realize benefits for patients.

Muslim-Christian Relations and Collaborative Efforts to Build Indonesia

Despite recent efforts to improve relations between Christian and Muslims in Indonesia, some Muslim groups continue to harbor prejudice against Christians, calling them infidels, followers of the religion of the hated Dutch, and allies of the Zionists. In addition, some Christian groups are actively seeking conversions in some Muslim groups. To reduce this prejudice, Christians must (1) cultivate a lifestyle that is less exclusive and more inclusive; (2) foster grassroots dialogue and collaboration (particularly regarding issues of the environment, human rights, and economic development); and (3) develop greater sensitivity about how and what they share about their ministry plans.

Care Gaps and Recommendations in Vestibular Migraine: An Expert Panel Summit

Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified in the 2012 Barany Society document and included in the third edition of the international classification of headache disorders, the pathophysiology of this disorder is still elusive. The Association for Migraine Disorders hosted a multidisciplinary, international expert workshop in October 2020 and identified seven current care gaps that the scientific community needs to resolve, including a better understanding of the range of symptoms and phenotypes of VM, the lack of a diagnostic marker, a better understanding of pathophysiologic mechanisms, as well as the lack of clear recommendations for interventions (nonpharmacologic and pharmacologic) and finally, the need for specific outcome measures that will guide clinicians as well as research into the efficacy of interventions. The expert group issued several recommendations to address those areas including establishing a global VM registry, creating an improved diagnostic algorithm using available vestibular tests as well as others that are in development, conducting appropriate trials of high quality to validate current clinically available treatment and fostering collaborative efforts to elucidate the pathophysiologic mechanisms underlying VM, specifically the role of the trigemino-vascular pathways.

Challenges and Opportunities in the Study of Innovation Ecosystems in the COVID-19 Pandemic Context

The process of knowledge construction, widely discussed in the literature, follows a common structure that encompasses transformation of data into information and then into knowledge, which converges social, technological, organizational, and strategic aspects. The advancement of information technologies and growing global research efforts in the health field has dynamically generated large datasets, thus providing potential innovative solutions to health problems, posing important challenges in selection and interpretation of useful information and possibilities. COVID-19 pandemic has intensified this data generation as results of global efforts, and cooperation has promoted a level of scientific production never experienced before concerning the overcoming of the pandemic. In this context, the search for an effective and safe vaccine that can prevent the spread of this virus has become a common goal of societies, governments, institutions, and companies. These collaborative efforts have contributed to speed up the development of these vaccines at an unprecedented pace in history.

Building Community Resilience Through Environmental Education

The call for collaborative efforts to respond to climate change is heeded through bilateral and multilateral agreements. The UN Sustainable Development Goals bears testimony to the call. Environmental education is one of the vehicles to raise awareness, understanding, and assessment of sustainable development goals at a community level to build resilience for sustainability. Environmental education enhances the accomplishment of the key competencies for sustainability. Climate change is a complex environmental problem that is not only naturally induced, but made more stressful by anthropocentric capabilities in the quest for a better lifestyle. Although climate change causes and impacts are known, its mitigation strategies are compounded by human wants at the expense of their own sustainable survival. This chapter explores ways of building sustainable development in communities. Environmental education is a core development strategy in local communities against the adverse impact of climate change, especially in vulnerable areas.

Collaboration Beyond the School

The authors of this chapter posit that collaboration with related and instructional personnel, as well as regional and state education agencies, can serve to combat teacher retention issues while improving student services. Acknowledging common barriers to effective collaboration, practical tools for overcoming these challenges are suggested. Further, key stakeholders in the collaborative process and their roles are identified. The chapter concludes by organizing collaborative efforts to engage in throughout a student's educational career.

A Critical Review of Secondary Educational Shifts to Online Learning Modalities in the COVID-19 Pandemic

The widespread impact of the COVID-19 pandemic affected K12 schools globally. This unprecedented disruption to education transformed teaching and learning experiences for children, teachers, administrators, and parents in many ways. The challenge of shifting traditional classroom teaching to online and distance modalities were met with various responses by school leaders and communities across the globe. This critical review highlights recent responses to continuing education for K12 students through collaborative efforts as the delivery of instruction as redefined and redesigned to meet the needs of children. Despite the lack of preparedness for this sudden shift to online learning, K12 district leaders and other stakeholders demonstrated their commitment to navigate through this crisis head-on. While disparities and unequal access became more evident during this unforeseen time, the future of online learning can be strengthened by this experience. This awareness can lead to further improvements in K12 education to serve all children with equity despite the circumstances.