This paper illustrates the operational difficulties arising from simultaneously performing exothermic and endothermic reactions, and demonstrates that a plant can be built and safely operated by integrating the design and plantwide control issues. The behaviour of reactor separation recycle systems carrying the coupled reactions A ?P + Q (endo) and B + Q ? R (exo) is investigated. Irrespective of the control structure, state multiplicity cannot be removed if the intermediate component Q is recycled. Therefore, the chemical reactor should be designed such that the recycle of Q can be avoided without economic penalty. The theoretical findings are applied to the design and control of a plant coupling ethylbenzene dehydrogenation and nitrobenzene hydrogenation for simultaneous production of styrene and aniline. After plant design, a rigorous dynamic model is developed using AspenDynamics. A plantwide control structure is implemented and shown to be able to achieve stable operation. Production rate changes of reasonable magnitude can be achieved by changing the reactor-inlet flow rates or bed-inlet temperature.