scholarly journals Probabilistic Modelling of Developmental Neurotoxicity based on a Simplified Adverse Outcome Pathway Network

2021 ◽  
pp. 100206
Author(s):  
Nicoleta Spînu ◽  
Mark T.D. Cronin ◽  
Junpeng Lao ◽  
Anna Bal-Price ◽  
Ivana Campia ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Developmental Neurotoxicity ◽  
Adverse Outcome Pathway ◽  
Probabilistic Modelling ◽  
Pathway Network

scholarly journals Assessment of developmental neurotoxicity induced by chemical mixtures using an adverse outcome pathway concept

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Francesca Pistollato ◽  
Emilio Mendoza de Gyves ◽  
Donatella Carpi ◽  
Stephanie K. Bopp ◽  
Carolina Nunes ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Developmental Neurotoxicity ◽  
Adverse Outcome Pathway ◽  
Chemical Mixtures

scholarly journals Adverse Outcome Pathway Network–Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function

2020 ◽  
Vol 39 (4) ◽  
pp. 913-922 ◽  
Author(s):  
Gerald T. Ankley ◽  
Brett R. Blackwell ◽  
Jenna E. Cavallin ◽  
Jon A. Doering ◽  
David J. Feifarek ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Aromatase Inhibitor ◽  
Receptor Agonist ◽  
Adverse Outcome ◽  
Interactive Effects ◽  
Endocrine Function ◽  
Adverse Outcome Pathway ◽  
Pathway Network

scholarly journals Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 86
Author(s):  
Magdalini Sachana ◽  
Timothy J. Shafer ◽  
Andrea Terron
Keyword(s):  
Adverse Outcome ◽  
Developmental Neurotoxicity ◽  
Adverse Outcome Pathway ◽  
Guidance Document ◽  
Chemical Safety ◽  
In Vivo Models ◽  
Animal Data

Characterization of potential chemical-induced developmental neurotoxicity (DNT) hazard is considered for risk assessment purposes by many regulatory sectors. However, due to test complexity, difficulty in interpreting results and need of substantial resources, the use of the in vivo DNT test guidelines has been limited and animal data on DNT are scarce. To address challenging endpoints such as DNT, the Organisation for Economic Co-Operation and Development (OECD) chemical safety program has been working lately toward the development of integrated approaches for testing and assessment (IATA) that rely on a combination of multiple layers of data (e.g., in vitro, in silico and non-mammalian in vivo models) that are supported by mechanistic knowledge organized according to the adverse outcome pathway (AOP) framework. In 2017, the OECD convened a dedicated OECD expert group to develop a guidance document on the application and interpretation of data derived from a DNT testing battery that relies on key neurodevelopmental processes and is complemented by zebrafish assays. This review will provide a brief overview of the OECD DNT project and summarize various achievements of relevance to the project. The review also presents an opportunity to describe considerations for uptake of the DNT in an in vitro battery in a regulatory context.

scholarly journals Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway

2020 ◽  
Vol 78 ◽  
pp. 209-241 ◽  
Author(s):  
Marta Barenys ◽  
Ingrid Reverte ◽  
Stefan Masjosthusmann ◽  
Jesús Gómez-Catalán ◽  
Ellen Fritsche
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Adverse Outcome ◽  
Developmental Neurotoxicity ◽  
Adverse Outcome Pathway

scholarly journals Development and analysis of an adverse outcome pathway network for human neurotoxicity

2019 ◽  
Vol 93 (10) ◽  
pp. 2759-2772 ◽  
Author(s):  
Nicoleta Spinu ◽  
Anna Bal-Price ◽  
Mark T. D. Cronin ◽  
Steven J. Enoch ◽  
Judith C. Madden ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Pathway Network

scholarly journals Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling

2020 ◽  
Vol 17 (1) ◽  
pp. 147-164 ◽  
Author(s):  
S Jannicke Moe ◽  
Raoul Wolf ◽  
Li Xie ◽  
Wayne G Landis ◽  
Niina Kotamäki ◽  
...  
Keyword(s):  
Bayesian Network ◽  
Adverse Outcome ◽  
Network Modeling ◽  
Bayesian Regression ◽  
Adverse Outcome Pathway ◽  
Pathway Network ◽  
Bayesian Network Modeling

scholarly journals Mechanistic study of chlordecone-induced endocrine disruption: Based on an adverse outcome pathway network

Chemosphere ◽  
2016 ◽  
Vol 161 ◽  
pp. 372-381 ◽  
Author(s):  
Lihua Yang ◽  
Bingsheng Zhou ◽  
Jinmiao Zha ◽  
Zijian Wang
Keyword(s):  
Endocrine Disruption ◽  
Adverse Outcome ◽  
Mechanistic Study ◽  
Adverse Outcome Pathway ◽  
Pathway Network

Derivation, characterisation and analysis of an adverse outcome pathway network for human hepatotoxicity

Toxicology ◽  
2021 ◽  
pp. 152856
Author(s):  
Emma Arnesdotter ◽  
Nicoleta Spinu ◽  
James Firman ◽  
David Ebbrell ◽  
Mark T.D. Cronin ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Pathway Network
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