A review of the endometrial histologic effects of progestins and progesterone receptor modulators in reproductive age women

Contraception ◽  
2015 ◽  
Vol 91 (5) ◽  
pp. 360-367 ◽  
Author(s):  
Anh Dinh ◽  
Intira Sriprasert ◽  
Alistair R. Williams ◽  
David F. Archer
Keyword(s):  
Progesterone Receptor ◽  
Reproductive Age ◽  
Reproductive Age Women ◽  
Receptor Modulators ◽  
Progesterone Receptor Modulators

scholarly journals 90 YEARS OF PROGESTERONE: Selective progesterone receptor modulators in gynaecological therapies

2020 ◽  
Vol 65 (1) ◽  
pp. T15-T33
Author(s):  
H O D Critchley ◽  
R R Chodankar
Keyword(s):  
Progesterone Receptor ◽  
Unmet Need ◽  
Abnormal Uterine Bleeding ◽  
Reproductive Age ◽  
Female Reproductive Health ◽  
Emergency Contraceptive ◽  
Health And Disease ◽  
Receptor Modulators ◽  
Selective Progesterone Receptor Modulators ◽  
Progesterone Receptor Modulators

Abnormal uterine bleeding (AUB) is a chronic, debilitating and common condition affecting one in four women of reproductive age. Current treatments (conservative, medical and surgical) may be unsuitable, poorly tolerated or may result in loss of fertility. Selective progesterone receptor modulators (SPRMs) influence progesterone-regulated pathways, a hormone critical to female reproductive health and disease; therefore, SPRMs hold great potential in fulfilling an unmet need in managing gynaecological disorders. SPRMs in current clinical use include RU486 (mifepristone), which is licensed for pregnancy interruption, and CDB-2914 (ulipristal acetate), licensed for managing AUB in women with leiomyomas and in a higher dose as an emergency contraceptive. In this article, we explore the clinical journey of SPRMs and the need for further interrogation of this class of drugs with the ultimate goal of improving women’s quality of life.

Current Progresses and Trends in the Development of Progesterone Receptor Modulators

2016 ◽  
Vol 23 (23) ◽  
pp. 2507-2554 ◽  
Author(s):  
Wenlu Li ◽  
Xi Li ◽  
Bin Zhang ◽  
Chunmei Gao ◽  
Yuzong Chen ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Receptor Modulators ◽  
Progesterone Receptor Modulators
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