scholarly journals Unraveling Unique and Common Cell Type-Specific Mechanisms in Glioblastoma Multiforme

2021 ◽  
Author(s):  
Samreen Fathima ◽  
Swati Sinha ◽  
Sainitin Donakonda
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Type ◽  
Cell Type Specific ◽  
Common Cell

scholarly journals IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

2016 ◽  
Author(s):  
Deborah Rotoli ◽  
Natalia Pérez-Rodríguez ◽  
Manuel Morales ◽  
María Del Carmen Maeso ◽  
Julio Ávila ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Normal Cell ◽  
Primary Brain Tumor ◽  
Cell Physiology ◽  
Positive Staining ◽  
Cell Type ◽  
Cellular Functions ◽  
Tissue Samples ◽  
Cell Type Specific ◽  
Human Gbm

Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopical analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol). Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology and also in oncologic processes.

scholarly journals IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

2017 ◽  
Author(s):  
Deborah Rotoli ◽  
Natalia Dolores Pérez-Rodríguez ◽  
Manuel Morales ◽  
María del Carmen Maeso ◽  
Julio Ávila ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Primary Brain Tumor ◽  
Cell Physiology ◽  
Positive Staining ◽  
Cell Type ◽  
Cellular Functions ◽  
Tissue Samples ◽  
Signalling Molecules ◽  
Cell Type Specific ◽  
Human Gbm

Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signalling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumours, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopical analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol. Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology and also in oncologic processes.

scholarly journals IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

2017 ◽  
Author(s):  
Deborah Rotoli ◽  
Natalia Pérez-Rodríguez ◽  
Manuel Morales ◽  
María Del Carmen Maeso ◽  
Julio Ávila ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Microscopic Analysis ◽  
Primary Brain Tumor ◽  
Cell Physiology ◽  
Positive Staining ◽  
Cell Type ◽  
Cellular Functions ◽  
Tissue Samples ◽  
Cell Type Specific ◽  
Human Gbm

Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor. GBM is formed by a very heterogeneous astrocyte population, neurons, neovascularization and infiltrating myeloid cells (microglia and monocyte derived macrophages). The IQGAP1 scaffold protein interacts with components of the cytoskeleton, cell adhesion molecules, and several signaling molecules to regulate cell morphology and motility, cell cycle and other cellular functions. IQGAP1 overexpression and delocalization has been observed in several tumors, suggesting a role for this protein in cell proliferation, transformation and invasion. IQGAP1 has been identified as a marker of amplifying cancer cells in GBMs. To determine the involvement of IQGAP1 in the onco-biology of GBM, we performed immunohistochemical confocal microscopic analysis of the IQGAP1 protein in human GBM tissue samples using cell type-specific markers. IQGAP1 immunostaining and subcellular localization was heterogeneous; the protein was located in the plasma membrane and, at variable levels, in nucleus and/or cytosol. Moreover, IQGAP1 positive staining was found in podosome/invadopodia-like structures. IQGAP1+ staining was observed in neurons (Map2+ cells), in cancer stem cells (CSC; nestin+) and in several macrophages (CD31+ or Iba1+). Our results indicate that the IQGAP1 protein is involved in normal cell physiology as well as oncologic processes.

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration

Cell Type–Specific Transcriptional and Epigenetic Profiles from a Rare Neuronal Population within the Arcuate Nucleus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2430-PUB
Author(s):  
FRANKIE D. HEYWARD ◽  
EVAN ROSEN
Keyword(s):  
Arcuate Nucleus ◽  
Neuronal Population ◽  
Cell Type ◽  
Cell Type Specific
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