piRNA-independent transposon silencing by the Drosophila THO complex

2021 ◽  
Author(s):  
Gen Zhang ◽  
Tianxiong Yu ◽  
Swapnil S. Parhad ◽  
Samantha Ho ◽  
Zhiping Weng ◽  
...  
Keyword(s):  
Transposon Silencing ◽  
Tho Complex

piRNA-Independent Transposon Silencing by The  Drosophila THO Complex

2021 ◽  
Author(s):  
Gen Zhang ◽  
Tianxiong Yu ◽  
Swapnil Parhad ◽  
Samantha Ho ◽  
Zhiping Weng ◽  
...  
Keyword(s):  
Transposon Silencing ◽  
Tho Complex

scholarly journals Transgene and Transposon Silencing in Chlamydomonas reinhardtii by a DEAH-Box RNA Helicase

Science ◽  
2000 ◽  
Vol 290 (5494) ◽  
pp. 1159-1162 ◽  
Author(s):  
D. Wu-Scharf
Keyword(s):  
Chlamydomonas Reinhardtii ◽  
Rna Helicase ◽  
Transposon Silencing

scholarly journals A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing

2012 ◽  
Vol 47 (6) ◽  
pp. 970-979 ◽  
Author(s):  
Jordi Xiol ◽  
Elisa Cora ◽  
Rubina Koglgruber ◽  
Shinichiro Chuma ◽  
Sailakshmi Subramanian ◽  
...  
Keyword(s):  
Transposon Silencing

scholarly journals Drosophila small ovary gene is required for transposon silencing and heterochromatin organization, and ensures germline stem cell maintenance and differentiation

Development ◽  
2018 ◽  
Vol 145 (23) ◽  
pp. dev170639 ◽  
Author(s):  
Ferenc Jankovics ◽  
Melinda Bence ◽  
Rita Sinka ◽  
Anikó Faragó ◽  
László Bodai ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Maintenance ◽  
Transposon Silencing ◽  
Small Ovary ◽  
Cell Maintenance

scholarly journals The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline

2021 ◽  
Author(s):  
Elisabeth A Marnik ◽  
Miguel Vasconcelos Almeida ◽  
P Giselle Cipriani ◽  
George Chung ◽  
Edoardo Caspani ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Small Rna ◽  
Small Rnas ◽  
Brood Size ◽  
Homologous Proteins ◽  
P Granules ◽  
Transposon Silencing ◽  
Tudor Domain ◽  
Germ Granules

LOTUS and Tudor domain containing proteins have critical roles in the germline. Proteins that contain these domains, such as Tejas/Tapas in Drosophila, help localize Vasa to the germ granules and facilitate piRNA-mediated transposon silencing. The homologous proteins in mammals, TDRD5 and TDRD7, are required during spermiogenesis. Until now, proteins containing both LOTUS and Tudor domains in Caenorhabditis elegans have remained elusive. Here we describe LOTR-1 (D1081.7), which derives its name from its LOTUS and Tudor domains. Interestingly, LOTR-1 docks next to P granules to colocalize with the broadly conserved Z-granule helicase, ZNFX-1. LOTR-1's Z-granule association requires its Tudor domain, but both LOTUS and Tudor deletions affect brood size when coupled with a knockdown of the Vasa homolog glh-1. In addition to interacting with the germ-granule components WAGO-1, PRG-1 and DEPS-1, we identified a Tudor-dependent association with ZNFX-1. Like znfx-1 mutants, lotr-1 mutants lose small RNAs from the 3' ends of WAGO and Mutator targets, reminiscent of the loss of piRNAs from the 3' ends of piRNA precursor transcripts in mouse Tdrd5 mutants. Our work suggests that LOTR-1 acts in a conserved mechanism that brings small RNA generating mechanisms towards the 3' ends of small RNA templates or precursors.

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