tho complex
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Author(s):  
Gen Zhang ◽  
Tianxiong Yu ◽  
Swapnil S. Parhad ◽  
Samantha Ho ◽  
Zhiping Weng ◽  
...  

2021 ◽  
Author(s):  
Gen Zhang ◽  
Tianxiong Yu ◽  
Swapnil Parhad ◽  
Samantha Ho ◽  
Zhiping Weng ◽  
...  

2020 ◽  
Vol 30 (10) ◽  
pp. 1978
Author(s):  
Zhenxia Su ◽  
Lihua Zhao ◽  
Yuanyuan Zhao ◽  
Shaofang Li ◽  
SoYoun Won ◽  
...  
Keyword(s):  

2019 ◽  
Author(s):  
Nan Zhang ◽  
Yongxu Zhao ◽  
Jianxia Chen ◽  
Qiurong Ding ◽  
Feng Liu
Keyword(s):  

Viruses ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 158 ◽  
Author(s):  
Tian-Sheng He ◽  
Tao Xie ◽  
Jing Li ◽  
Ya-Xian Yang ◽  
Changsheng Li ◽  
...  

RNA virus invasion induces a cytosolic RIG-I-like receptor (RLR) signaling pathway by promoting assembly of the Mitochondrial antiviral-signaling protein (MAVS) signalosome and triggers the rapid production of type I interferons (IFNs) and proinflammatory cytokines. During this process, the pivotal kinase TANK binding kinase 1 (TBK1) is recruited to the MAVS signalosome to transduce a robust innate antiviral immune response by phosphorylating transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor (NF)-κB and promoting their nuclear translocation. However, the molecular mechanisms underlying the negative regulation of TBK1 are largely unknown. In the present study, we found that THO complex subunit 7 homolog (THOC7) negatively regulated the cellular antiviral response by promoting the proteasomal degradation of TBK1. THOC7 overexpression potently inhibited Sendai virus- or polyI:C-induced IRF3 dimerization and phosphorylation and IFN-β production. In contrast, THOC7 knockdown had the opposite effects. Moreover, we simulated a node-activated pathway to show that THOC7 regulated the RIG-I-like receptors (RLR)-/MAVS-dependent signaling cascade at the TBK1 level. Furthermore, THOC7 was involved in the MAVS signalosome and promoted TBK1 degradation by increasing its K48 ubiquitin-associated polyubiquitination. Together, these findings suggest that THOC7 negatively regulates type I IFN production by promoting TBK1 proteasomal degradation, thus improving our understanding of innate antiviral immune responses.


2019 ◽  
Vol 84 ◽  
pp. 105-114 ◽  
Author(s):  
Rosa Luna ◽  
Ana G. Rondón ◽  
Carmen Pérez-Calero ◽  
Irene Salas-Armenteros ◽  
Andrés Aguilera
Keyword(s):  

Cell ◽  
2018 ◽  
Vol 174 (6) ◽  
pp. 1436-1449.e20 ◽  
Author(s):  
Celine I. Maeder ◽  
Jae-Ick Kim ◽  
Xing Liang ◽  
Konstantin Kaganovsky ◽  
Ao Shen ◽  
...  

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