A controlled clinical trial on antiviral therapy (peginterferon alfa-2A (40KD)+ribavirin) for the treatment of chronic hepatitis C in patients on haemodialysis awaiting renal transplant

2007 ◽  
Vol 39 (3) ◽  
pp. A13-A14
Author(s):  
M. Rendina ◽  
A. Schena ◽  
N.M. Castellaneta ◽  
F. Losito ◽  
A.C. Amoruso ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Renal Transplant ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Controlled Clinical Trial ◽  
Peginterferon Alfa

scholarly journals Solanum Fruit Juice as a Natural and Sustainable Source of Antioxidants for Patients with Chronic Hepatitis C under Antiviral Therapy

2018 ◽  
Author(s):  
Chidiebere Uchenna Iheka ◽  
Justice Obinna Osuoha ◽  
Idongesit Ekong Archibong ◽  
Peter Uchenna Amadi ◽  
Oluwatoyin Taiwo Adeoti
Keyword(s):  
Clinical Trial ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Body Mass ◽  
Fruit Juice ◽  
Control Group ◽  
Marker Enzyme ◽  
Atherogenic Indices

Variations in liver metabolism as a result of hepatitis C virus have been established by numerous clinical trials. The use of antioxidants supplements has been reported to minimize the implication of this disease. In this regard, we examined the suitability of Solanum fruit juice, a natural source of vitamin C and citrus flavoniod as a precursor for the treatment of patients with chronic hepatitis C. Forty adult patients who were diagnosed with chronic hepatitis C and were under antiviral therapy were divided into two equal groups. Group 1 patients received their antiviral therapy with normal food and water and served as the control group while patients in group 2 were supplemented with Solanum fruit juice for eight consecutive weeks. Measurements for Anthropometric data, C reactive protein (CRP), atherogenic indices, biochemical parameters and activities of liver marker enzymes were recorded before and after eight weeks. No alterations were found in waist circumference, body mass and body fat following regular use of Solanum fruit juice. The serum levels of oxidative stress markers, LDL-cholesterol, total cholesterol, CRP and atherogenic indices decreased in the Solanum fruit juice group when compared to the control group. Moreover, the activities of the liver marker enzyme AST decreased in those who had high levels before the intervention. These results underscore the benefits of Solanum fruit juice in the diet of patients with HCV as a result of decreased cholesterol in blood serum, decreased inflammation, and increase in antioxidant capacity as well as maintaining body mass index. This clinical trial is registered at Pan African Clinical Trial Registry (www.pactr.org) with unique identification number PACTR201802003092138.

The treatment of chronic hepatitis C with peginterferon alfa-2a (40kDa) plus ribavirin in haemodialysed patients awaiting renal transplant

2007 ◽  
Vol 46 (5) ◽  
pp. 768-774 ◽  
Author(s):  
Maria Rendina ◽  
Antonio Schena ◽  
Nicola Maurizio Castellaneta ◽  
Francesco Losito ◽  
Anna Cinzia Amoruso ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Renal Transplant ◽  
Chronic Hepatitis C ◽  
Peginterferon Alfa
Sign in / Sign up

Export Citation Format

Share Document