Role of cytochrome P450 and UDP-glucuronosyltransferases in metabolic pathway of homoegonol in human liver microsomes

2015 ◽  
Vol 30 (4) ◽  
pp. 305-313 ◽  
Author(s):  
Soon Sang Kwon ◽  
Ju Hyun Kim ◽  
Hyeon-Uk Jeong ◽  
Kyung-Seop Ahn ◽  
Sei-Ryang Oh ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Pathway ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes

Bioactivation of aflatoxin B1 by human liver microsomes: Role of cytochrome P450 IIIA enzymes

1991 ◽  
Vol 108 (3) ◽  
pp. 436-447 ◽  
Author(s):  
Howard S. Ramsdell ◽  
Andrew Parkinson ◽  
A.Craig Eddy ◽  
David L. Eaton
Keyword(s):  
Cytochrome P450 ◽  
Aflatoxin B1 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes

scholarly journals In Vitro Metabolism Study of Seongsanamide A in Human Liver Microsomes Using Non-Targeted Metabolomics and Feature-Based Molecular Networking

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1031
Author(s):  
Zhexue Wu ◽  
Geum Jin Kim ◽  
So-Young Park ◽  
Jong Cheol Shon ◽  
Kwang-Hyeon Liu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Metabolic Pathway ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Targeted Metabolomics ◽  
Molecular Networking ◽  
Cytochrome P450 Isoforms ◽  
Feature Based

Seongsanamide A is a bicyclic peptide with an isodityrosine residue discovered in Bacillus safensis KCTC 12796BP which exhibits anti-allergic activity in vitro and in vivo without significant cytotoxicity. The purpose of this study was to elucidate the in vitro metabolic pathway and potential for drug interactions of seongsanamide A in human liver microsomes using non-targeted metabolomics and feature-based molecular networking (FBMN) techniques. We identified four metabolites, and their structures were elucidated by interpretation of high-resolution tandem mass spectra. The primary metabolic pathway associated with seongsanamide A metabolism was hydroxylation and oxidative hydrolysis. A reaction phenotyping study was also performed using recombinant cytochrome P450 isoforms. CYP3A4 and CYP3A5 were identified as the major metabolic enzymes responsible for metabolite formation. Seongsanamide A did not inhibit the cytochrome P450 isoforms commonly involved in drug metabolism (IC50 > 10 µM). These results will contribute to further understanding the metabolism and drug interaction potential of various bicyclic peptides.

Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

2007 ◽  
Vol 36 (2) ◽  
pp. 380-385 ◽  
Author(s):  
Damaris S. Diaz ◽  
Michael. P. Kozar ◽  
Kirsten S. Smith ◽  
Constance O. Asher ◽  
Jason C. Sousa ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Isoforms

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study
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