Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5Reductase in Variability of CYP3A Activity in Human Liver Microsomes

Cyp3a Activity ◽

Nadph Cytochrome ◽

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1992.tb17027.x ◽

1992 ◽

Vol 207 (1) ◽

pp. 109-116 ◽

Cited By ~ 62

Author(s):

Marie-Anne PEYRONNEAU ◽

Jean-Paul RENAUD ◽

Gilles TRUAN ◽

Philippe URBAN ◽

Denis POMPON ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Liver ◽

Cytochrome B5 ◽

Cytochrome P450 3A4 ◽

Catalytic Activities ◽

Liver Cytochrome ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Probing the role of lysines and arginines in the catalytic function of cytochrome P450d by site-directed mutagenesis. Interaction with NADPH-cytochrome P450 reductase

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67801-4 ◽

1991 ◽

Vol 266 (6) ◽

pp. 3372-3375

Author(s):

T Shimizu ◽

T Tateishi ◽

M Hatano ◽

Y Fujii-Kuriyama

Keyword(s):

Cytochrome P450 ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Catalytic Function ◽

Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase. Implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells

Anti-Cancer Drugs ◽

10.1097/cad.0b013e32834fcf4f ◽

2012 ◽

Vol 23 (4) ◽

pp. 393-405 ◽

Cited By ~ 5

Author(s):

Dorota Kostrzewa-Nowak ◽

Bohdan Bieg ◽

Mark J.I. Paine ◽

C. Roland Wolf ◽

Jolanta Tarasiuk

Keyword(s):

Cytochrome P450 ◽

Multidrug Resistant ◽

Structural Factors ◽

Hl60 Cells ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anthraquinone Derivatives ◽

Role of the prosthetic groups of NADPH-cytochrome P450 reductase in 3-hydroxyanthranilamide-catalyzed, NADPH-dependent superoxide anion production

Redox Report ◽

10.1080/13510002.1996.11747070 ◽

1996 ◽

Vol 2 (5) ◽

pp. 339-344

Author(s):

Y. Ohta ◽

R. Shinohara ◽

I. Ishiguro

Keyword(s):

Cytochrome P450 ◽

Superoxide Anion ◽

Superoxide Anion Production ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Anion Production ◽

Nadph Cytochrome P450 Reductase ◽

Prosthetic Groups

Reduction of cytochrome b5 by NADPH–cytochrome P450 reductase

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2005.06.019 ◽

2005 ◽

Vol 440 (2) ◽

pp. 204-211 ◽

Cited By ~ 56

Author(s):

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Features of the local immobilization of NADPH-cytochrome P450 reductase and cytochrome b5 on a solid surface

Russian Journal of General Chemistry ◽

10.1134/s1070363210060046 ◽

2010 ◽

Vol 80 (6) ◽

pp. 1060-1063

Author(s):

I. V. Paribok ◽

G. K. Zhavnerko ◽

V. E. Agabekov ◽

A. V. Yantsevich ◽

S. A. Usanov

Keyword(s):

Cytochrome P450 ◽

Solid Surface ◽

Cytochrome B5 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

The Primate Adrenal Zona Reticularis is Defined by Expression of Cytochrome b5, 17 -hydroxylase/17,20-lyase Cytochrome P450 (P450c17) and NADPH-Cytochrome P450 Reductase (reductase) but not 3 -Hydroxysteroid Dehydrogenase/ 5-4 Isomerase (3 -HSD)

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.84.9.3382 ◽

1999 ◽

Vol 84 (9) ◽

pp. 3382-3385 ◽

Cited By ~ 21

Author(s):

S. Mapes

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Hydroxysteroid Dehydrogenase ◽

Zona Reticularis ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Cytochrome b5 and NADPH‐Cytochrome P450 Reductase Compete for a Binding Site on the Proximal Surface of Cytochrome P450 2B4

The FASEB Journal ◽

10.1096/fasebj.21.5.a670-d ◽

2007 ◽

Vol 21 (5) ◽

Author(s):

Lucy Waskell ◽

Haoming Zhang ◽

Sang‐Choul Im ◽

Reza Razeghifard

Keyword(s):

Cytochrome P450 ◽

Binding Site ◽

Cytochrome B5 ◽

Proximal Surface ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Cytochrome P450 2B4 ◽

Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5 enzymes

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2004.12.008 ◽

2005 ◽

Vol 435 (1) ◽

pp. 207-216 ◽

Cited By ~ 52

Author(s):

Tsutomu Shimada ◽

Raymond L. Mernaugh ◽

F. Peter Guengerich

Keyword(s):

Cytochrome P450 ◽

Cytochrome B5 ◽

Nadph Cytochrome ◽

P450 Reductase ◽

Role of LYS271 and LYS279 Residues in the Interaction of Cytochrome P4501A1 with NADPH–Cytochrome P450 Reductase

Archives of Biochemistry and Biophysics ◽

10.1006/abbi.2000.2174 ◽

2001 ◽

Vol 385 (2) ◽

pp. 290-300 ◽

Cited By ~ 9

Author(s):

Tomas Cvrk ◽

Henry W. Strobel

Keyword(s):

Cytochrome P450 ◽

Cytochrome P4501a1 ◽

Nadph Cytochrome ◽

P450 Reductase ◽