MetMax™ pooled donor human hepatocytes: A novel in vitro system for the evaluation of hepatic drug metabolism

2018 ◽  
Vol 33 (1) ◽  
pp. S61
Author(s):  
David Ho ◽  
Nick Ring ◽  
Kirsten Amaral ◽  
Albert P. Li
Keyword(s):  
Drug Metabolism ◽  
Human Hepatocytes ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
In Vitro System

Vitamin A Status and Hepatic Drug Metabolism in the Rat

1973 ◽  
Vol 51 (1) ◽  
pp. 6-11 ◽  
Author(s):  
G. C. Becking
Keyword(s):  
Vitamin A ◽  
Drug Metabolism ◽  
Vitamin A Deficiency ◽  
Hepatic Drug Metabolism ◽  
Deficient Diet ◽  
Hepatic Drug ◽  
Vitamin A Status ◽  
Cytochrome P 450 ◽  
Liver Vitamin

The effect of vitamin A status on hepatic drug metabolism was studied in rats. Animals were fed diets with and without vitamin A for 20 and 25 days. Weight gains of control and deficient animals were not significantly different, whereas liver vitamin A levels had decreased to less than 10% of control animals after 20 days and were essentially zero after eating the deficient diet for 25 days. Aniline metabolism in vitro and aminopyrine metabolism in vitro and in vivo were significantly lower in male weanling rats fed a vitamin A deficient diet for 20 days. No alteration in in vitro p-nitrobenzoic acid metabolism was noted after 25 days on the test. Vitamin A deficiency did not alter microsomal protein levels or cytochrome c reductase activity but deficient animals did have a lower microsomal cytochrome P-450 content. Hepatic enzyme activities and cytochrome P-450 levels were restored to values approaching those found in control animals by feeding vitamin A deficient rats the vitamin A containing diet for 21 days. Liver vitamin A levels were markedly increased after re-feeding studies but were still significantly lower than control animals.

Hepatic drug metabolism in vitro in the horse

1971 ◽  
Vol 20 (11) ◽  
pp. 3219-3221 ◽  
Author(s):  
Roger A. Yeary ◽  
Diane Gerken
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

A comparison of in vitro and in vivo methods for evaluating alterations in hepatic drug metabolism following mercuric chloride administration

1986 ◽  
Vol 32 (1-2) ◽  
pp. 133-140 ◽  
Author(s):  
Bruce A. Trela ◽  
Gary P. Carlson ◽  
Robert W. Chadwick ◽  
M.Frank Copeland
Keyword(s):  
Drug Metabolism ◽  
Mercuric Chloride ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

In Vitro Methods for Assessing Human Hepatic Drug Metabolism: Their use in Drug Development

1993 ◽  
Vol 25 (4) ◽  
pp. 453-484 ◽  
Author(s):  
Steven A. Wrighton ◽  
Mark Vandenbranden ◽  
Jeffrey C. Stevens ◽  
Lisa A. Shipley ◽  
Barbara J. Ring ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Drug Development ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
In Vitro Methods

In vitro assessment of hepatic drug metabolism in man: a clinical pharmacological perspective

1982 ◽  
Vol 3 ◽  
pp. 487-490 ◽  
Author(s):  
Christer von Bahr ◽  
Hans Glaumann ◽  
Britt Mellström ◽  
Folke Sjöqvist
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
In Vitro Assessment

scholarly journals In Vitro Method for Assessing Hepatic Drug Metabolism.

1997 ◽  
Vol 20 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Mitsunobu OKUYAMA ◽  
Chieko INOUE ◽  
Keiko AIJIMA ◽  
Yachiyo NAKAMURA ◽  
Takayuki KABURAGI ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
In Vitro Method
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