A solvent free, four-component synthesis and 1,3-dipolar cycloaddition of 4(H)-pyrans with nitrile oxides: Synthesis and discovery of antimycobacterial activity of enantiomerically pure 1,2,4-oxadiazoles

2012 ◽  
Vol 53 ◽  
pp. 416-423 ◽  
Author(s):  
Abdulrahman I. Almansour ◽  
Raju Suresh Kumar ◽  
Natarajan Arumugam ◽  
Dharmarajan Sriram
Keyword(s):  
Antimycobacterial Activity ◽  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Enantiomerically Pure ◽  
Nitrile Oxides

scholarly journals Synthesis of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of tomentosin

RSC Advances ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. 6523-6529 ◽  
Author(s):  
Mohamed Zaki ◽  
Abdelouahd Oukhrib ◽  
Mohamed Akssira ◽  
Sabine Berteina-Raboin
Keyword(s):  
Double Bond ◽  
Dipolar Cycloaddition ◽  
Exocyclic Double Bond ◽  
Enantiomerically Pure ◽  
Nitrile Oxides ◽  
Dittrichia Viscosa ◽  
Derivatives Of

A series of novel enantiomerically pure spiro-(isoxazolidines/isoxazolines) were synthesized regioselectively by 1,3-dipolar cycloaddition using nitrones and nitrile oxides, on the exocyclic double bond of tomentosin extracted from Dittrichia viscosa.

Synthesis of carbohydrate-substituted isoxazoles and evaluation of their antitubercular activity

2017 ◽  
Vol 23 (3) ◽  
pp. 225-229 ◽  
Author(s):  
Khaoula Hajlaoui ◽  
Ahlem Guesmi ◽  
Naoufel Ben Hamadi ◽  
Moncef Msaddek
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Minimum Inhibitory Concentration ◽  
Bacterial Strain ◽  
Inhibitory Concentration ◽  
Cycloaddition Reaction ◽  
Antitubercular Activity ◽  
Antimycobacterial Activity ◽  
Dipolar Cycloaddition ◽  
Nitrile Oxides ◽  
Mycobacterium Tuberculosis H37rv

AbstractEight new sugar-substituted isoxazoles were synthesized by a 1,3-dipolar cycloaddition reaction of aromatic nitrile oxides with carbohydrate-substituted alkynes. Products were screened for antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain. Four compounds, 5e–h, significantly inhibit growth of the bacterial strain with a minimum inhibitory concentration (MIC) of 3.125 μg/mL.

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