Synthesis of carbohydrate-substituted isoxazoles and evaluation of their antitubercular activity
Keyword(s):
AbstractEight new sugar-substituted isoxazoles were synthesized by a 1,3-dipolar cycloaddition reaction of aromatic nitrile oxides with carbohydrate-substituted alkynes. Products were screened for antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain. Four compounds, 5e–h, significantly inhibit growth of the bacterial strain with a minimum inhibitory concentration (MIC) of 3.125 μg/mL.
1994 ◽
Vol 59
(1)
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pp. 234-238
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2016 ◽
Vol 8
(12)
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pp. 252
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