Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors

2013 ◽  
Vol 68 ◽  
pp. 58-71 ◽  
Author(s):  
Zhi-Hong Huang ◽  
Shi-Tian Zhuo ◽  
Chun-Yan Li ◽  
Hua-Ting Xie ◽  
Ding Li ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of benzimidazole–rhodanine conjugates as potent topoisomerase II inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 1194-1205 ◽  
Author(s):  
Penghui Li ◽  
Wenjin Zhang ◽  
Hong Jiang ◽  
Yongliang Li ◽  
Changzhi Dong ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Cytotoxic Activities ◽  
Design Synthesis ◽  
Topoisomerase Ii Inhibitors ◽  
Topo Ii ◽  
Synthesis And Biological Evaluation

In this study, a series of benzimidazole–rhodanine conjugates were designed, synthesized and investigated for their topoisomerase II (Topo II) inhibitory and cytotoxic activities.

Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents

2016 ◽  
Vol 66 ◽  
pp. 145-159 ◽  
Author(s):  
Pritam Thapa ◽  
Tara Man Kadayat ◽  
Seojeong Park ◽  
Somin Shin ◽  
Til Bahadur Thapa Magar ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Cytotoxic Agents ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors

2018 ◽  
Vol 28 (8) ◽  
pp. 1320-1323 ◽  
Author(s):  
Hong Jiang ◽  
Wen-Jin Zhang ◽  
Peng-Hui Li ◽  
Jian Wang ◽  
Chang-Zhi Dong ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Antitumor Agents. 185.†Synthesis and Biological Evaluation of Tridemethylthiocolchicine Analogues as Novel Topoisomerase II Inhibitors

1998 ◽  
Vol 41 (11) ◽  
pp. 1956-1961 ◽  
Author(s):  
Jian Guan ◽  
Xiao-Kang Zhu ◽  
Yoko Tachibana ◽  
Kenneth F. Bastow ◽  
Arnold Brossi ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

Synthesis and biological evaluation of new 2,5-dimethylthiophene/furan based N-acetyl pyrazolines as selective topoisomerase II inhibitors

RSC Advances ◽  
2016 ◽  
Vol 6 (18) ◽  
pp. 14880-14892 ◽  
Author(s):  
Darpan Darpan ◽  
Gaurav Joshi ◽  
Suyog M. Amrutkar ◽  
Ashish T. Baviskar ◽  
Harveen Kler ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Biological Evaluation ◽  
Topoisomerase Inhibitors ◽  
Topoisomerase Ii Inhibitors ◽  
Synthesis And Biological Evaluation

Based on reported pharmacophores as topoisomerase inhibitors, 2,5-dimethylthiophene/furan basedN-acetyl pyrazolines were designed and envisaged as topoisomerase inhibitors.

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