Synthesis, radiolabeling and preliminary in vivo evaluation of multimodal radiotracers for PET imaging and targeted radionuclide therapy of pigmented melanoma

2015 ◽  
Vol 92 ◽  
pp. 818-838 ◽  
Author(s):  
Emilie M.F. Billaud ◽  
Aurélie Maisonial-Besset ◽  
Latifa Rbah-Vidal ◽  
Aurélien Vidal ◽  
Sophie Besse ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Radionuclide Therapy ◽  
Targeted Radionuclide Therapy ◽  
In Vivo Evaluation

Synthesis, Radiofluorination, and in Vivo Evaluation of Novel Fluorinated and Iodinated Radiotracers for PET Imaging and Targeted Radionuclide Therapy of Melanoma

2013 ◽  
Vol 56 (21) ◽  
pp. 8455-8467 ◽  
Author(s):  
Emilie M. F. Billaud ◽  
Latifa Rbah-Vidal ◽  
Aurélien Vidal ◽  
Sophie Besse ◽  
Sébastien Tarrit ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Radionuclide Therapy ◽  
Targeted Radionuclide Therapy ◽  
In Vivo Evaluation

scholarly journals Multifunctional Cyanine-Based Theranostic Probe for Cancer Imaging and Therapy

2021 ◽  
Vol 22 (22) ◽  
pp. 12214
Author(s):  
Cheng-Liang Peng ◽  
Ying-Hsia Shih ◽  
Ping-Fang Chiang ◽  
Chun-Tang Chen ◽  
Ming-Cheng Chang
Keyword(s):  
Photothermal Therapy ◽  
Radionuclide Therapy ◽  
Nuclear Imaging ◽  
Biological Evaluation ◽  
Targeted Radionuclide Therapy ◽  
Nir Fluorescence ◽  
Tumor Accumulation ◽  
Selective Accumulation

Cancer is one of the leading causes of death in the world. A cancer-targeted multifunctional probe labeled with the radionuclide has been developed to provide multi-modalities for NIR fluorescence and nuclear imaging (PET, SPECT), for photothermal therapy (PTT), and targeted radionuclide therapy of cancer. In this study, synthesis, characterization, in vitro, and in vivo biological evaluation of the cyanine-based probe (DOTA-NIR790) were demonstrated. The use of cyanine dyes for the selective accumulation of cancer cells were used to achieve the characteristics of tumor markers. Therefore, all kinds of organ tumors can be targeted for diagnosis and treatment. The DOTA-NIR790 labeled with lutetium-111 could detect original or metastatic tumors by using SPECT imaging and quantify tumor accumulation. The β-emission of 177Lu-DOTA-NIR790 can be used for targeted radionuclide therapy of tumors. The DOTA-NIR790 enabled imaging by NIR fluorescence and by nuclear imaging (SPECT) to monitor in real-time the tumor accumulation and the situation of cancer therapy, and to guide the surgery or the photothermal therapy of the tumor. The radionuclide-labeled heptamethine cyanine based probe (DOTA-NIR790) offers multifunctional modalities for imaging and therapies of cancer.

scholarly journals In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies

Theranostics ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 104-117 ◽  
Author(s):  
Kristell L.S. Chatalic ◽  
Mark Konijnenberg ◽  
Julie Nonnekens ◽  
Erik de Blois ◽  
Sander Hoeben ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Receptor Antagonist ◽  
Pet Imaging ◽  
Radionuclide Therapy ◽  
Preclinical Studies ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide

scholarly journals In Vivo Evaluation of11C-Preladenant for PET Imaging of Adenosine A2AReceptors in the Conscious Monkey

2017 ◽  
Vol 58 (5) ◽  
pp. 762-767 ◽  
Author(s):  
Xiaoyun Zhou ◽  
Ronald Boellaard ◽  
Kiichi Ishiwata ◽  
Muneyuki Sakata ◽  
Rudi A.J.O. Dierckx ◽  
...  
Keyword(s):  
Pet Imaging ◽  
In Vivo Evaluation

Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N′-[4-(2-fluoroethoxy)benzyl]piperazine, a novel σ1 receptor PET imaging agent

2011 ◽  
Vol 21 (22) ◽  
pp. 6820-6823 ◽  
Author(s):  
Iman A. Moussa ◽  
Samuel D. Banister ◽  
Nicolas Giboureau ◽  
Steven R. Meikle ◽  
Michael Kassiou
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
In Vivo Evaluation ◽  
Σ1 Receptor

Improved radiosynthesis and preliminary in vivo evaluation of a 18F-labeled glycopeptide–peptoid hybrid for PET imaging of neurotensin receptor 2

2015 ◽  
Vol 23 (14) ◽  
pp. 4026-4033 ◽  
Author(s):  
Simone Maschauer ◽  
Cornelia Greff ◽  
Jürgen Einsiedel ◽  
Julian Ott ◽  
Philipp Tripal ◽  
...  
Keyword(s):  
Pet Imaging ◽  
In Vivo Evaluation ◽  
Neurotensin Receptor

68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers

2012 ◽  
Vol 39 (4) ◽  
pp. 560-569 ◽  
Author(s):  
Morten Persson ◽  
Jacob Madsen ◽  
Søren Østergaard ◽  
Michael Ploug ◽  
Andreas Kjaer
Keyword(s):  
Pet Imaging ◽  
In Vivo Evaluation

Radiosynthesis and in vivo evaluation of [ 11 C]MOV as a PET imaging agent for COX-2

2018 ◽  
Vol 28 (14) ◽  
pp. 2432-2435 ◽  
Author(s):  
Jaya Prabhakaran ◽  
Mark Underwood ◽  
Francesca Zanderigo ◽  
Norman R. Simpson ◽  
Anna R. Cooper ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Imaging Agent ◽  
In Vivo Evaluation ◽  
Cox 2

Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor

2018 ◽  
Vol 26 (16) ◽  
pp. 4650-4663 ◽  
Author(s):  
Marcel Lindemann ◽  
Sonja Hinz ◽  
Winnie Deuther-Conrad ◽  
Vigneshwaran Namasivayam ◽  
Sladjana Dukic-Stefanovic ◽  
...  
Keyword(s):  
Pet Imaging ◽  
In Vivo Evaluation ◽  
Adenosine A2b Receptor ◽  
A2b Receptor ◽  
Adenosine A2b
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