Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure–activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure–activity relationships

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.07.034 ◽

2010 ◽

Vol 18 (21) ◽

pp. 7675-7699 ◽

Cited By ~ 17

Author(s):

Shigeo Hayashi ◽

Eriko Nakata ◽

Asato Morita ◽

Kunihiko Mizuno ◽

Kenzo Yamamura ◽

...

Keyword(s):

Neuropathic Pain ◽

Orphanin Fq ◽

Design Synthesis ◽

Structure Activity ◽

Peptide Agonist

Design, synthesis and structure-activity relationships of novel N11-, C12- and C13-substituted 15-membered homo-aza-clarithromycin derivatives against various resistant bacteria

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104992 ◽

2021 ◽

pp. 104992

Author(s):

Yinhui Qin ◽

Di Song ◽

Yuetai Teng ◽

Xingbang Liu ◽

Panpan Zhang ◽

...

Keyword(s):

Resistant Bacteria ◽

Design Synthesis ◽

Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112222 ◽

2020 ◽

Vol 193 ◽

pp. 112222 ◽

Cited By ~ 3

Author(s):

Bing-Zhi Fan ◽

Hiroshi Hiasa ◽

Wei Lv ◽

Scott Brody ◽

Zhao-Yong Yang ◽

...

Keyword(s):

Design Synthesis ◽

Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.01.104 ◽

2007 ◽

Vol 17 (8) ◽

pp. 2171-2178 ◽

Cited By ~ 8

Author(s):

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Junko Tamiya ◽

Mingzhu Zhang ◽

Brian Dyck ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.06.049 ◽

2006 ◽

Vol 16 (18) ◽

pp. 4922-4930 ◽

Cited By ~ 10

Author(s):

Sarah Hudson ◽

Mehrak Kiankarimi ◽

Martin W. Rowbottom ◽

Troy D. Vickers ◽

Dongpei Wu ◽

...

Keyword(s):

Small Molecule ◽

Hormone Receptor ◽

Structure Activity ◽

Melanin Concentrating Hormone

Design, synthesis and structure–activity relationships of new phosphinate inhibitors of MurD

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.09.086 ◽

2006 ◽

Vol 16 (2) ◽

pp. 343-348 ◽

Cited By ~ 42

Author(s):

Katja Štrancar ◽

Didier Blanot ◽

Stanislav Gobec

Keyword(s):

Design Synthesis ◽

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

Journal of Medicinal Chemistry ◽

10.1021/jm900519b ◽

2009 ◽

Vol 52 (16) ◽

pp. 5020-5031 ◽

Cited By ~ 62

Author(s):

Sunil K. Vooturi ◽

Chrissy M. Cheung ◽

Michael J. Rybak ◽

Steven M. Firestine

Keyword(s):

Antibacterial Agents ◽

Design Synthesis ◽

Application of “Hydrogen-Bonding Interaction” in Drug Design. Part 2: Design, Synthesis, and Structure–Activity Relationships of Thiophosphoramide Derivatives as Novel Antiviral and Antifungal Agents

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.5b02676 ◽

2015 ◽

Vol 63 (43) ◽

pp. 9435-9440 ◽

Cited By ~ 11

Author(s):

Aidang Lu ◽

Yuanyuan Ma ◽

Ziwen Wang ◽

Zhenghong Zhou ◽

Qingmin Wang

Keyword(s):

Hydrogen Bonding ◽

Drug Design ◽

Antifungal Agents ◽

Hydrogen Bonding Interaction ◽

Design Synthesis ◽

Structure Activity ◽

Bonding Interaction

New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.011 ◽

2013 ◽

Vol 68 ◽

pp. 433-443 ◽

Cited By ~ 20

Author(s):

Sébastien Fortin ◽

Kevin Brasseur ◽

Nathalie Morin ◽

Éric Asselin ◽

Gervais Bérubé

Keyword(s):

Prostate Cancer ◽

Biological Evaluation ◽

Design Synthesis ◽

Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure–Activity Relationships

Synthesis ◽

10.1055/s-0035-1561456 ◽

2016 ◽

Vol 48 (17) ◽

pp. 2739-2756 ◽

Cited By ~ 3

Author(s):

Daniele Piomelli ◽

Eleonora Diamanti ◽

Giovanni Bottegoni ◽

Luca Goldoni ◽

Natalia Realini ◽

...

Keyword(s):

Acid Ceramidase ◽

Design Synthesis ◽