Design, synthesis and structure–activity relationships of new phosphinate inhibitors of MurD

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.09.086 ◽

2006 ◽

Vol 16 (2) ◽

pp. 343-348 ◽

Author(s):

Katja Štrancar ◽

Didier Blanot ◽

Stanislav Gobec

Keyword(s):

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis and structure-activity relationships of novel N11-, C12- and C13-substituted 15-membered homo-aza-clarithromycin derivatives against various resistant bacteria

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104992 ◽

2021 ◽

pp. 104992

Author(s):

Yinhui Qin ◽

Di Song ◽

Yuetai Teng ◽

Xingbang Liu ◽

Panpan Zhang ◽

...

Keyword(s):

Resistant Bacteria ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure–activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.02.014 ◽

2016 ◽

Vol 114 ◽

pp. 345-364 ◽

Author(s):

Shigeo Hayashi ◽

Katsuyo Ohashi ◽

Sachiko Mihara ◽

Eriko Nakata ◽

Chie Emoto ◽

...

Keyword(s):

Small Molecule ◽

Orphanin Fq ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112222 ◽

2020 ◽

Vol 193 ◽

pp. 112222 ◽

Author(s):

Bing-Zhi Fan ◽

Hiroshi Hiasa ◽

Wei Lv ◽

Scott Brody ◽

Zhao-Yong Yang ◽

...

Keyword(s):

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

Journal of Medicinal Chemistry ◽

10.1021/jm900519b ◽

2009 ◽

Vol 52 (16) ◽

pp. 5020-5031 ◽

Author(s):

Sunil K. Vooturi ◽

Chrissy M. Cheung ◽

Michael J. Rybak ◽

Steven M. Firestine

Keyword(s):

Antibacterial Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Application of “Hydrogen-Bonding Interaction” in Drug Design. Part 2: Design, Synthesis, and Structure–Activity Relationships of Thiophosphoramide Derivatives as Novel Antiviral and Antifungal Agents

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.5b02676 ◽

2015 ◽

Vol 63 (43) ◽

pp. 9435-9440 ◽

Author(s):

Aidang Lu ◽

Yuanyuan Ma ◽

Ziwen Wang ◽

Zhenghong Zhou ◽

Qingmin Wang

Keyword(s):

Hydrogen Bonding ◽

Drug Design ◽

Antifungal Agents ◽

Hydrogen Bonding Interaction ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Bonding Interaction

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New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.011 ◽

2013 ◽

Vol 68 ◽

pp. 433-443 ◽

Author(s):

Sébastien Fortin ◽

Kevin Brasseur ◽

Nathalie Morin ◽

Éric Asselin ◽

Gervais Bérubé

Keyword(s):

Prostate Cancer ◽

Biological Evaluation ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure–Activity Relationships

Synthesis ◽

10.1055/s-0035-1561456 ◽

2016 ◽

Vol 48 (17) ◽

pp. 2739-2756 ◽

Author(s):

Daniele Piomelli ◽

Eleonora Diamanti ◽

Giovanni Bottegoni ◽

Luca Goldoni ◽

Natalia Realini ◽

...

Keyword(s):

Acid Ceramidase ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

New Journal of Chemistry ◽

10.1039/c9nj04713a ◽

2020 ◽

Vol 44 (6) ◽

pp. 2247-2255

Author(s):

Qifan Zhou ◽

Lina Jia ◽

Fangyu Du ◽

Xiaoyu Dong ◽

Wanyu Sun ◽

...

Keyword(s):

Biological Activity ◽

Anticancer Agents ◽

Biological Activities ◽

Activity Assay ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

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Design, synthesis, and structure–activity relationships of indole-3-heterocycles as agonists of the CB1 receptor

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.093 ◽

2011 ◽

Vol 21 (1) ◽

pp. 506-509 ◽

Author(s):

Angus J. Morrison ◽

Julia M. Adam ◽

James A. Baker ◽

Robert A. Campbell ◽

John K. Clark ◽

...

Keyword(s):

Cb1 Receptor ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-l-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H-imidazole-5-carboxylic acid (CI-996)

Journal of Medicinal Chemistry ◽

10.1021/jm00068a002 ◽

1993 ◽

Vol 36 (16) ◽

pp. 2253-2265 ◽

Author(s):

Ila Sircar ◽

John C. Hodges ◽

John Quin ◽

Amy M. Bunker ◽

R. Thomas Winters ◽

...

Keyword(s):

Angiotensin Ii ◽

Carboxylic Acid ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Imidazole Derivatives ◽

Structure Activity

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