Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.05.010 ◽

2018 ◽

Vol 156 ◽

pp. 162-179 ◽

Author(s):

Qinhuai Lai ◽

Yuxi Wang ◽

Ruixue Wang ◽

Weirong Lai ◽

Liangze Tang ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitor ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site

Bioorganic Chemistry ◽

10.1016/j.bioorg.2020.103695 ◽

2020 ◽

Vol 97 ◽

pp. 103695

Author(s):

Xi Hu ◽

Lu Li ◽

Qiangsheng Zhang ◽

Qianqian Wang ◽

Zhanzhan Feng ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitor ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00715 ◽

2021 ◽

Author(s):

Hao Chen ◽

Shanshan Deng ◽

Najah Albadari ◽

Mi-Kyung Yun ◽

Sicheng Zhang ◽

...

Keyword(s):

Binding Site ◽

Anticancer Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitors ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of resveratrol-cinnamoyl derivates as tubulin polymerization inhibitors targeting the colchicine binding site

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103319 ◽

2019 ◽

Vol 93 ◽

pp. 103319 ◽

Author(s):

Yong Yin ◽

Bao-Ping Lian ◽

Yuan-Zheng Xia ◽

Yu-Ying Shao ◽

Ling-Yi Kong

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Tubulin Polymerization ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Tubulin Polymerization Inhibitors ◽

Synthesis And Biological Evaluation

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Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b00706 ◽

2019 ◽

Vol 62 (14) ◽

pp. 6734-6750 ◽

Author(s):

Qinghui Wang ◽

Kinsie E. Arnst ◽

Yuxi Wang ◽

Gyanendra Kumar ◽

Dejian Ma ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b00071 ◽

2016 ◽

Vol 59 (11) ◽

pp. 5341-5355 ◽

Author(s):

Yan-Na Liu ◽

Jing-Jing Wang ◽

Ya-Ting Ji ◽

Guo-Dong Zhao ◽

Long-Qian Tang ◽

...

Keyword(s):

Binding Site ◽

Anticancer Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.11.070 ◽

2019 ◽

Vol 163 ◽

pp. 428-442 ◽

Author(s):

Wenlong Li ◽

Wen Shuai ◽

Honghao Sun ◽

Feijie Xu ◽

Yi Bi ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Indole Derivatives ◽

Design Synthesis ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents

Journal of Medicinal Chemistry ◽

10.1021/jm500764v ◽

2014 ◽

Vol 57 (17) ◽

pp. 7355-7366 ◽

Author(s):

Yan Lu ◽

Jianjun Chen ◽

Jin Wang ◽

Chien-Ming Li ◽

Sunjoo Ahn ◽

...

Keyword(s):

Binding Site ◽

Anticancer Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Tubulin Inhibitors ◽

Colchicine Binding Site ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of new carbazole-coumarin hybrids as dual binding site inhibitors of acetylcholinesterase

Journal of Molecular Structure ◽

10.1016/j.molstruc.2020.129784 ◽

2021 ◽

Vol 1229 ◽

pp. 129784

Author(s):

Meng-qiu Song ◽

Wei Min ◽

Jing Wang ◽

Xi-Xi Si ◽

Xiu-Jun Wang ◽

...

Keyword(s):

Binding Site ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of 7H-Thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Dual Binding Site Acetylcholinesterase Inhibitors

Heterocycles ◽

10.3987/com-18-12820 ◽

2013 ◽

Vol 87 (12) ◽

Author(s):

Chun Hu ◽

Si-Jie Liu ◽

Li-Bo Cui ◽

Hiu-Lan Xu ◽

Tie-Ying Wang ◽

...

Keyword(s):

Binding Site ◽

Acetylcholinesterase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease

Journal of Medicinal Chemistry ◽

10.1021/jm0503289 ◽

2005 ◽

Vol 48 (23) ◽

pp. 7223-7233 ◽

Author(s):

Pilar Muñoz-Ruiz ◽

Laura Rubio ◽

Esther García-Palomero ◽

Isabel Dorronsoro ◽

María del Monte-Millán ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Site ◽

Acetylcholinesterase Inhibitors ◽

Biological Evaluation ◽

New Disease ◽

Design Synthesis ◽

Disease Modifying ◽

Disease Modifying Agents ◽

Synthesis And Biological Evaluation

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