Abnormal Exacerbation of Moderately Differentiated Gastric Adenocarcinoma in a Patient with TAFRO Syndrome: An Impaired Tumor Immunity?

TAFRO syndrome is a relatively new disease entity first reported in 2010. We report a case of TAFRO syndrome accommodated by abnormal exacerbation of moderately differentiated gastric adenocarcinoma. The pathophysiology of TAFRO syndrome is largely unknown, but because the disease often responds to immunosuppressive therapy and also because T follicular helper (Tfh) cells are reported to be drastically decreased in TAFRO syndrome, involvement of a dysregulated immune system can be speculated. Growing evidence points toward a pivotal role of Tfh cells in tumor immunity through supporting ectopic lymphoid structures, which are recruitment sites for cells directly engaging in antitumor activity such as CD8⁺ T cells, NK cells, and macrophages. In fact, Tfh cells are reported to positively correlate with longer survival in human colorectal and breast cancer. Combined with our observations of hyperprogressive gastric cancer in the presented patient, an impaired tumor immunity is strongly indicated in TAFRO syndrome.

Application of Mathematical Modeling in Prediction of COVID-19 Transmission Dynamics

The entire world has been affected by the outbreak of COVID-19 since early 2020. Human carriers are largely the spreaders of this new disease, and it spreads much faster compared to previously identified coronaviruses and other flu viruses. Although vaccines have been invented and released, it will still be a challenge to overcome this disease. To save lives, it is important to better understand how the virus is transmitted from one host to another and how future areas of infection can be predicted. Recently, the second wave of infection has hit multiple countries, and governments have implemented necessary measures to tackle the spread of the virus. We investigated the three phases of COVID-19 research through a selected list of mathematical modeling articles. To take the necessary measures, it is important to understand the transmission dynamics of the disease, and mathematical modeling has been considered a proven technique in predicting such dynamics. To this end, this paper summarizes all the available mathematical models that have been used in predicting the transmission of COVID-19. A total of nine mathematical models have been thoroughly reviewed and characterized in this work, so as to understand the intrinsic properties of each model in predicting disease transmission dynamics. The application of these nine models in predicting COVID-19 transmission dynamics is presented with a case study, along with detailed comparisons of these models. Toward the end of the paper, key behavioral properties of each model, relevant challenges and future directions are discussed.

Development of Disease-Resistance-Associated Microsatellite DNA Markers for Selective Breeding of Tilapia (Oreochromis spp.) Farmed in Taiwan

There are numerous means to improve the tilapia aquaculture industry, and one is to develop disease resistance through selective breeding using molecular markers. In this study, 11 disease-resistance-associated microsatellite markers including 3 markers linked to hamp2, 4 linked to hamp1, 1 linked to pgrn2, 2 linked to pgrn1, and 1 linked to piscidin 4 (TP4) genes were established for tilapia strains farmed in Taiwan after challenge with Streptococcus inae. The correlation analysis of genotypes and survival revealed a total of 55 genotypes related to survival by the chi-square and Z-test. Although fewer markers were found in B and N2 strains compared with A strain, they performed well in terms of disease resistance. It suggested that this may be due to the low potency of some genotypes and the combinatorial arrangement between them. Therefore, a predictive model was built by the genotypes of the parental generation and the mortality rate of different combinations was calculated. The results show the same trend of predicted mortality in the offspring of three new disease-resistant strains as in the challenge experiment. The present findings is a nonkilling method without requiring the selection by challenge with bacteria or viruses and might increase the possibility of utilization of selective breeding using SSR markers in farms.

A Review on Myths and Facts about COVID-19

Background: Myth is widely held but false idea or a belief. It is usually backed by religious, traditional , customs and rituals which tries to manipulate public mindset. Since the spread of Covid-19 Pandemic, myths are being believed by people .In this review article I am providing information about Myths and its actual facts about COVID-19 which are essential to be known so as to stop the spread of Myths by some set of people for own gains or either due to lack of Scientific Information It takes too long to debunk a myth by presenting facts. Conclusion: Myths have been believed by common people at large whenever a new disease or virus is identified. These Myths have potential to spread more vigorously than the virus itself Myths can have detrimental effects on various aspects of physical, mental and social health. These myths should be curbed by providing evidence based information which can stop its spread. Therefore strict possible measures as discussed above should be taken by respective authorities.

Post-covid syndrome in children

Multisystem inflammatory syndrome in children associated with COVID-19 is a new disease, information first appeared in April 2020. There were reported cases of hospitalized children with unusual symptoms, manifested primarily by fever and multisystem inflammation from the pediatricians in the UK and other countries during the coronavirus infection pandemic (COVID-19). Some of these children were in critical condition with symptoms of shock and multiple organ failure, and some children had manifestations similar to Kawasaki disease. Despite the fact that COVID-19 in children is relatively easy, some of the «convalescents» after 2–6 weeks develop symptoms largely identical to the manifestations of severe forms of new coronavirus infection in adults. The report presents own clinical cases of multisystem inflammatory syndrome that developed in children after acute form of a new coronavirus infection. The authors discuss the possible clinical variants of the syndrome, its origin and outcomes.

Sexsomnia in a patient with lichen planopilaris and pulsed corticosteroid prescription

Sleep sex or sexsomnia is a relatively new disease that is considered an unusual sexual experience and behavior. Many facts about sexsomnia, including its causes, symptoms, and exact prevalence, are still unknown. Given that the symptoms of the disease occur accidentally during the night, it is tough to study this disease in the long run. This study reported a case of a 30-year-old man with sexsomnia who had no recollection of the sexual behavior he exhibited while asleep. He had lichen planopilaris and was not receiving any psychiatric medication at the time of the study. However, he was under treatment with corticosteroids for six months, which eventually worsened his depression. This behavior attracted his wife's attention, and he was referred to a doctor due to infertility.

Effects of Isolation Among Older Adults Due to Coronavirus Restrictions

Semi-structured interviews were conducted with 35 residents in a Maryland condominium, four to six months after the presence of the epidemic in the US was recognized in mid-March. The objective was to determine to what extent the restrictions resulting from the presence of a new disease was affecting older adults in their daily lives, and in their plans for the future. All respondents were over the age of 60 and half were more than 80 years old. Two-thirds lived by themselves; most others lived with a husband or wife. Respondents for the most part were following guidelines to wear masks, practice social distancing and avoid close contact with persons outside their homes, including other family members. Over half had already made dramatic changes in their daily activities. Some found an opportunity to develop new skills, had connected with people from the past, or had become more introspective. Others, while exhibiting some of the same characteristics, were more focused on the restrictions they faced, and were more aware than ever of the limited amount of time left in their lives. Differences between respondents in the emphasis of their perspectives are explored, by age, gender, and other characteristics.

UPAYA PEMERINTAH DAERAH DALAM PENANGANAN PANDEMI COVID-19 DI KABUPATEN GARUT

The pandemic that is endemic throughout the world is making every country work hard to eradicate it. has been declared by the World Health Organization (WHO) as a Global Public Health Emergency which is known to spread to all corners of the world very quickly. Coronavirus is a new virus that causes illness ranging from mild to severe symptoms. There are at least two types of corona viruses that cause serious illness, namely Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). Coronavirus disease 2019 (COVID-19) is a new disease that has never been identified in humans. The virus that causes is called SarsCoV2. COVID-19 is a new disease and there is very little research on it. Evidence-based information is required for the care, treatment and other information related to this disease. The Indonesian government later declared the Corona problem as an unnatural or non-natural national disaster. The President of the Republic of Indonesia, regional governments and their staff work together in various efforts to prevent the spread of the virus in the community. From ministerial level to province, district or city Keywords: Pandemic, Local Government, Efforts