Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112354 ◽

2020 ◽

Vol 198 ◽

pp. 112354

Author(s):

Guofeng Xu ◽

Yan Zhang ◽

Hai Wang ◽

Zhuang Guo ◽

Xiaowei Wang ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Pyrazole Derivatives ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.04.071 ◽

2010 ◽

Vol 18 (12) ◽

pp. 4459-4467 ◽

Cited By ~ 23

Author(s):

Dae-Kee Kim ◽

Yeon-Im Lee ◽

Yeon Woo Lee ◽

Purushottam M. Dewang ◽

Yhun Yhong Sheen ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.05.032 ◽

2010 ◽

Vol 20 (14) ◽

pp. 4228-4232 ◽

Cited By ~ 22

Author(s):

Purushottam M. Dewang ◽

Dae-Kee Kim

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation ◽

Substituted Pyrazoles

Download Full-text

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.05.063 ◽

2011 ◽

Vol 46 (9) ◽

pp. 3917-3925 ◽

Cited By ~ 21

Author(s):

Cheng Hua Jin ◽

Domalapally Sreenu ◽

Maddeboina Krishnaiah ◽

Vura Bala Subrahmanyam ◽

Kota Sudhakar Rao ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles and 1,3,5-trisubstituted pyrazoles as inhibitors of transforming growth factor β type 1 receptor (ALK5)

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.04.066 ◽

2009 ◽

Vol 19 (16) ◽

pp. 4868-4872 ◽

Cited By ~ 17

Author(s):

Xingzhou Li ◽

Lili Wang ◽

Long Long ◽

Junhai Xiao ◽

Yuandong Hu ◽

...

Keyword(s):

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2011.08.064 ◽

2011 ◽

Vol 21 (20) ◽

pp. 6049-6053 ◽

Cited By ~ 22

Author(s):

Cheng Hua Jin ◽

Maddeboina Krishnaiah ◽

Domalapally Sreenu ◽

Vura Bala Subrahmanyam ◽

Kota Sudhakar Rao ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

ChemInform Abstract: Synthesis and Biological Evaluation of 1-(6-Methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitors.

ChemInform ◽

10.1002/chin.201324160 ◽

2013 ◽

Vol 44 (24) ◽

pp. no-no

Author(s):

Fei Li ◽

Yunjeong Park ◽

Jung-Mi Hah ◽

Jae-Sang Ryu

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and Biological Evaluation of 4(5)-(6-Alkylpyridin-2-yl)imidazoles as Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm070129k ◽

2007 ◽

Vol 50 (13) ◽

pp. 3143-3147 ◽

Cited By ~ 34

Author(s):

Dae-Kee Kim ◽

Yoojeung Jang ◽

Ho Soon Lee ◽

Hyun-Ju Park ◽

Jakyung Yoo

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.03.024 ◽

2009 ◽

Vol 44 (2) ◽

pp. 568-576 ◽

Cited By ~ 15

Author(s):

Dae-Kee Kim ◽

Sun Hee Jung ◽

Ho Soon Lee ◽

Purushottam M. Dewang

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.09.011 ◽

2012 ◽

Vol 57 ◽

pp. 74-84 ◽

Cited By ~ 12

Author(s):

Maddeboina Krishnaiah ◽

Cheng Hua Jin ◽

Domalapally Sreenu ◽

Vura Bala Subrahmanyam ◽

Kota Sudhakar Rao ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.03.008 ◽

2011 ◽

Vol 19 (8) ◽

pp. 2633-2640 ◽

Cited By ~ 21

Author(s):

Cheng Hua Jin ◽

Maddeboina Krishnaiah ◽

Domalapally Sreenu ◽

Kota Sudhakar Rao ◽

Vura Bala Subrahmanyam ◽

...

Keyword(s):

Growth Factor ◽

Kinase Inhibitors ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Biological Evaluation ◽

Receptor Kinase ◽

Synthesis And Biological Evaluation

Download Full-text