Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer’s disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112475 ◽

2020 ◽

Vol 202 ◽

pp. 112475

Author(s):

Sai-Sai Xie ◽

Jing Liu ◽

Chunli Tang ◽

Chengyun Pang ◽

Qing Li ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.07.031 ◽

2019 ◽

Vol 180 ◽

pp. 367-382 ◽

Author(s):

Changjun Zhang ◽

Ke Yang ◽

Sihang Yu ◽

Jing Su ◽

Shengli Yuan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Iron Chelates ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer’s disease

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2017.09.055 ◽

2017 ◽

Vol 27 (22) ◽

pp. 5053-5059 ◽

Author(s):

Zhipei Sang ◽

Keren Wang ◽

Huifang Wang ◽

Lintao Yu ◽

Huijuan Wang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 3,4-dihydro-2(1 H )-quinoline- O -alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.03.070 ◽

2017 ◽

Vol 25 (12) ◽

pp. 3006-3017 ◽

Author(s):

Zhipei Sang ◽

Wanli Pan ◽

Keren Wang ◽

Qinge Ma ◽

Lintao Yu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113554 ◽

2021 ◽

pp. 113554

Author(s):

Wenwu Liu ◽

Xin Liu ◽

Liting Tian ◽

Yaping Gao ◽

Wenjie Liu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Gsk 3Β ◽

Synthesis And Biological Evaluation

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Phthalimide‐(N‐alkylbenzylamine) cysteamide hybrids as multifunctional agents against Alzheimer’s disease: Design, synthesis and biological evaluation

Chemical Biology & Drug Design ◽

10.1111/cbdd.13905 ◽

2021 ◽

Author(s):

Heng Zhang ◽

Qing Song ◽

Guangjun Yu ◽

Zhongcheng Cao ◽

Xiaoming Qiang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Multifunctional Agents ◽

Synthesis And Biological Evaluation

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Synthesis and biological evaluation of novel radioiodinated imidazopyridine derivatives for amyloid-β imaging in Alzheimer’s disease

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.05.043 ◽

2014 ◽

Vol 22 (15) ◽

pp. 4189-4197 ◽

Author(s):

Chun-Jen Chen ◽

Kazunori Bando ◽

Hiroki Ashino ◽

Kazumi Taguchi ◽

Hideaki Shiraishi ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Imidazopyridine Derivatives ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.02.063 ◽

2018 ◽

Vol 149 ◽

pp. 129-138 ◽

Author(s):

Yuying Fang ◽

Wenjuan Xia ◽

Bao Cheng ◽

Pei Hua ◽

Huihao Zhou ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.02.008 ◽

2019 ◽

Vol 29 (8) ◽

pp. 1012-1018 ◽

Author(s):

Kai Cheng ◽

Shiyu Li ◽

Xiao Lv ◽

Yongbin Tian ◽

Haiyan Kong ◽

...

Keyword(s):

Crystal Structure ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

X Ray ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer’s Disease

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00376 ◽

2018 ◽

Vol 10 (1) ◽

pp. 537-551 ◽

Author(s):

Jinhui Hu ◽

Ya-Dan Huang ◽

Tingting Pan ◽

Tianhua Zhang ◽

Tao Su ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

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Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Bioorganic Chemistry ◽

10.1016/j.bioorg.2020.103721 ◽

2020 ◽

Vol 98 ◽

pp. 103721 ◽

Author(s):

Ana Xu ◽

Feng He ◽

Xiangna Zhang ◽

Xiaoyang Li ◽

Yingying Ran ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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