Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

Phthalimide‐(N‐alkylbenzylamine) cysteamide hybrids as multifunctional agents against Alzheimer’s disease: Design, synthesis and biological evaluation

Chemical Biology & Drug Design ◽

10.1111/cbdd.13905 ◽

2021 ◽

Author(s):

Heng Zhang ◽

Qing Song ◽

Guangjun Yu ◽

Zhongcheng Cao ◽

Xiaoming Qiang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Multifunctional Agents ◽

Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer's disease

10.1016/j.ejmech.2018.02.063 ◽

2018 ◽

Vol 149 ◽

pp. 129-138 ◽

Cited By ~ 7

Author(s):

Yuying Fang ◽

Wenjuan Xia ◽

Bao Cheng ◽

Pei Hua ◽

Huihao Zhou ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer's disease

10.1016/j.ejmech.2019.07.031 ◽

2019 ◽

Vol 180 ◽

pp. 367-382 ◽

Cited By ~ 10

Author(s):

Changjun Zhang ◽

Ke Yang ◽

Sihang Yu ◽

Jing Su ◽

Shengli Yuan ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Iron Chelates ◽

Design Synthesis ◽

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer’s Disease

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.8b00376 ◽

2018 ◽

Vol 10 (1) ◽

pp. 537-551 ◽

Cited By ~ 7

Author(s):

Jinhui Hu ◽

Ya-Dan Huang ◽

Tingting Pan ◽

Tianhua Zhang ◽

Tao Su ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Dual Target

Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer’s disease

10.1016/j.ejmech.2020.112257 ◽

2020 ◽

Vol 198 ◽

pp. 112257

Author(s):

Yash Pal Singh ◽

Gullanki Naga Venkata Charan Tej ◽

Amruta Pandey ◽

Khushbu Priya ◽

Pankaj Pandey ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Multifunctional Molecules ◽

Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer’s disease

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2014.03.058 ◽

2014 ◽

Vol 24 (10) ◽

pp. 2368-2373 ◽

Cited By ~ 5

Author(s):

Zi-Chen Xu ◽

Xiao-Bing Wang ◽

Wen-Ying Yu ◽

Sai-Sai Xie ◽

Su-Yi Li ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Multifunctional Agents ◽

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.7b00345 ◽

2017 ◽

Vol 9 (2) ◽

pp. 328-345 ◽

Cited By ~ 21

Author(s):

Fei Mao ◽

Huan Wang ◽

Wei Ni ◽

Xinyu Zheng ◽

Manjiong Wang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

First Generation ◽

Biological Evaluation ◽

Selective Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Phosphodiesterase 5 ◽

Dual Target

Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

10.1016/j.ejmech.2013.10.068 ◽

2014 ◽

Vol 71 ◽

pp. 36-45 ◽

Cited By ~ 60

Author(s):

Su-Yi Li ◽

Xiao-Bing Wang ◽

Ling-Yi Kong

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Targeted Agents ◽

Design Synthesis ◽

Resveratrol Derivatives ◽

Design, synthesis and biological evaluation of 2-Phenyl-4H-chromen-4-one derivatives as polyfunctional compounds against Alzheimer’s disease

Medicinal Chemistry Research ◽

10.1007/s00044-017-2078-4 ◽

2017 ◽

Vol 27 (2) ◽

pp. 520-530 ◽

Cited By ~ 2

Author(s):

Manjinder Singh ◽

Maninder Kaur ◽

Bhawna Vyas ◽

Om Silakari

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Biological Evaluation ◽

Design Synthesis ◽

Polyfunctional Compounds ◽

Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease

Journal of Medicinal Chemistry ◽

10.1021/jm0503289 ◽

2005 ◽

Vol 48 (23) ◽

pp. 7223-7233 ◽

Cited By ~ 143

Author(s):

Pilar Muñoz-Ruiz ◽

Laura Rubio ◽

Esther García-Palomero ◽

Isabel Dorronsoro ◽

María del Monte-Millán ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Site ◽

Acetylcholinesterase Inhibitors ◽

Biological Evaluation ◽

New Disease ◽

Design Synthesis ◽

Disease Modifying ◽

Disease Modifying Agents ◽