Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine

2006 ◽  
Vol 530 (1-2) ◽  
pp. 23-32 ◽  
Author(s):  
Yi Liu ◽  
Mary Lou Lubin ◽  
Tasha L. Reitz ◽  
Yan Wang ◽  
Raymond W. Colburn ◽  
...  
Keyword(s):  
Molecular Identification ◽  
Transient Receptor Potential ◽  
Functional Characterization ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Temperature Sensitive ◽  
Transient Receptor

scholarly journals Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes

Endocrinology ◽  
2017 ◽  
Vol 158 (4) ◽  
pp. 887-902 ◽  
Author(s):  
Andreas Beck ◽  
Viktoria Götz ◽  
Sen Qiao ◽  
Petra Weissgerber ◽  
Veit Flockerzi ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Functional Characterization ◽  
Receptor Potential ◽  
Trp Channel ◽  
Transient Receptor

Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity

2006 ◽  
Vol 291 (3) ◽  
pp. R518-R529 ◽  
Author(s):  
Martin Wechselberger ◽  
Chadwick L. Wright ◽  
Georgia A. Bishop ◽  
Jack A. Boulant
Keyword(s):  
Transient Receptor Potential ◽  
Neuronal Cell ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Ionic Channels ◽  
Temperature Sensitive ◽  
Neuronal Cell Bodies ◽  
Electrophysiological Studies ◽  
Channel Expression ◽  
Transient Receptor

Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. Immunohistochemical procedures identified the extent of various ionic channels in rat PO/AH neurons. These included pacemaker current channels [i.e., hyperpolarization-activated cyclic nucleotide-gated channels (HCN)], background potassium leak channels (TASK-1 and TRAAK), and transient receptor potential channel (TRP) TRPV4. PO/AH neurons showed dense TASK-1 and HCN-2 immunoreactivity and moderate TRAAK and HCN-4 immunoreactivity. In contrast, the neuronal cell bodies did not label for TRPV4, but instead, punctate labeling was observed in traversing axons or their terminal endings. On the basis of these results and previous electrophysiological studies, Hodgkin–Huxley-like models were constructed. These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons.

scholarly journals Molecular and Functional Characterization of a Novel Mouse Transient Receptor Potential Protein Homologue TRP7

1999 ◽  
Vol 274 (39) ◽  
pp. 27359-27370 ◽  
Author(s):  
Takaharu Okada ◽  
Ryuji Inoue ◽  
Kazuto Yamazaki ◽  
Akito Maeda ◽  
Tomohiro Kurosaki ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Functional Characterization ◽  
Receptor Potential ◽  
Transient Receptor
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