Correlation between algogenic effects of calcitonin-gene-related peptide (CGRP) and activation of trigeminal vascular system, in an in vivo experimental model of nitroglycerin-induced sensitization

2014 ◽  
Vol 740 ◽  
pp. 97-102 ◽  
Author(s):  
Alessandro Capuano ◽  
Maria Cristina Greco ◽  
Pierluigi Navarra ◽  
Giuseppe Tringali
Keyword(s):  
Experimental Model ◽  
Vascular System ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

An in vivo rat model to study calcitonin gene related peptide release following activation of the trigeminal vascular system

Pain ◽  
2001 ◽  
Vol 92 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Volker Limmroth ◽  
Zaza Katsarava ◽  
Bernd Liedert ◽  
Hans Guehring ◽  
Kerstin Schmitz ◽  
...  
Keyword(s):  
Rat Model ◽  
Vascular System ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Peptide Release

Induction of insulin resistance in vivo by amylin and calcitonin gene-related peptide

Diabetes ◽  
1990 ◽  
Vol 39 (2) ◽  
pp. 260-265 ◽  
Author(s):  
J. M. Molina ◽  
G. J. Cooper ◽  
B. Leighton ◽  
J. M. Olefsky
Keyword(s):  
Insulin Resistance ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene-Related Peptide

Diabetes ◽  
1990 ◽  
Vol 39 (2) ◽  
pp. 260-265 ◽  
Author(s):  
J. M. Molina ◽  
G. J. S. Cooper ◽  
B. Leighton ◽  
J. M. Olefsky
Keyword(s):  
Insulin Resistance ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene–Related Peptide Signaling through Endothelial Cells

2022 ◽  
pp. ji2100139
Author(s):  
Wanhong Ding ◽  
Lori L. Stohl ◽  
Jad Saab ◽  
Shayan Azizi ◽  
Xi K. Zhou ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Peptide Signaling ◽  
Cutaneous Immunity ◽  
Calcitonin Gene

scholarly journals Calcitonin gene-related peptide promotes Schwann cell proliferation.

1995 ◽  
Vol 129 (3) ◽  
pp. 789-796 ◽  
Author(s):  
L Cheng ◽  
M Khan ◽  
A W Mudge
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Schwann Cells ◽  
Neutral Endopeptidase ◽  
Calcitonin Gene Related Peptide ◽  
Intracellular Camp ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Glial Growth Factor

Schwann cells in culture divide in response to defined mitogens such as PDGF and glial growth factor (GGF), but proliferation is greatly enhanced if agents such as forskolin, which increases Schwann cell intracellular cAMP, are added at the same time as PDGF or GGF (Davis, J. B., and P. Stroobant. 1990. J. Cell Biol. 110:1353-1360). The effect of forskolin is probably due to an increase in numbers of PDGF receptors (Weinmaster, G., and G. Lemke. 1990. EMBO (Eur. Mol. Biol. Organ.) J. 9:915-920. Neuropeptides and beta-adrenergic agonists have been reported to have no effect on potentiating the mitogenic response of either PDGF or GGF. We show that the neuropeptide calcitonin gene-related peptide (CGRP) increases Schwann cell cAMP levels, but the cells rapidly desensitize. We therefore stimulated the cells in pulsatile fashion to partly overcome the effects of desensitization and show that CGRP can synergize with PDGF to stimulate Schwann cell proliferation, and that CGRP is as effective as forskolin in the pulsatile regime. CGRP is a good substrate for the neutral endopeptidase 24.11. Schwann cells in vivo have this protease on their surface, so the action of CGRP could be terminated by this enzyme and desensitization prevented. We therefore suggest that CGRP may play an important role in stimulating Schwann cell proliferation by regulating the response of mitogenic factors such as PDGF.

scholarly journals Calcitonin gene-related peptide promotes transient radiocalcium uptake into chick bone in vivo

1991 ◽  
Vol 76 (1) ◽  
pp. 143-146 ◽  
Author(s):  
AK Ancill ◽  
ZA Bascal ◽  
G Whitaker ◽  
CG Dacke
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo

2012 ◽  
Vol 166 (4) ◽  
pp. 1261-1271 ◽  
Author(s):  
Paul I Mapp ◽  
Daniel F McWilliams ◽  
Matthew J Turley ◽  
Edward Hargin ◽  
David A Walsh
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Calcitonin Gene Related Peptide ◽  
Endothelial Cell Proliferation ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene-related peptide inhibits early B cell development in vivo

2006 ◽  
Vol 81 (3) ◽  
pp. 802-808 ◽  
Author(s):  
Jerome J. Schlomer ◽  
Benjamin B. Storey ◽  
Radu-Tudor Ciornei ◽  
Joseph P. McGillis
Keyword(s):  
B Cell ◽  
Calcitonin Gene Related Peptide ◽  
Cell Development ◽  
B Cell Development ◽  
Related Peptide ◽  
Calcitonin Gene
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