In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ 2 -isoxazoline molecular skeleton

Receptor Agonist ◽

Nicotinic Acetylcholine ◽

Molecular Skeleton

Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays

Biochemical Pharmacology ◽

10.1016/j.bcp.2015.07.006 ◽

2015 ◽

Vol 97 (4) ◽

pp. 576-589 ◽

Cited By ~ 19

Author(s):

Milan Stoiljkovic ◽

Liza Leventhal ◽

Angela Chen ◽

Ting Chen ◽

Rachelle Driscoll ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Response Relationship ◽

Nicotinic Acetylcholine ◽

In Vivo Assays ◽

Relationship Of

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.04.070 ◽

2008 ◽

Vol 18 (12) ◽

pp. 3611-3615 ◽

Cited By ~ 43

Author(s):

Brad A. Acker ◽

E. Jon Jacobsen ◽

Bruce N. Rogers ◽

Donn G. Wishka ◽

Steven C. Reitz ◽

...

Keyword(s):

Acetylcholine Receptor ◽

In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites

PLoS Neglected Tropical Diseases ◽

10.1371/journal.pntd.0006506 ◽

2018 ◽

Vol 12 (5) ◽

pp. e0006506 ◽

Cited By ~ 4

Author(s):

Yan Hu ◽

Melanie Miller ◽

Bo Zhang ◽

Thanh-Thanh Nguyen ◽

Martin K. Nielsen ◽

...

Keyword(s):

Combination Therapy ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Unique Combination ◽

Nicotinic Acetylcholine ◽

Intestinal Nematode ◽

Nematode Parasites

ChemInform Abstract: Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo [2,3-c]pyridine-5-carboxamide as an Agonist of the α7 Nicotinic Acetylcholine Receptor: In vitro and in vivo Activity.

ChemInform ◽

10.1002/chin.200845225 ◽

2008 ◽

Vol 39 (45) ◽

Author(s):

Daniel P. Walker ◽

et al. et al.

Keyword(s):

Acetylcholine Receptor ◽

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models

Journal of Medicinal Chemistry ◽

10.1021/jm9015075 ◽

2010 ◽

Vol 53 (3) ◽

pp. 1222-1237 ◽

Cited By ~ 53

Author(s):

Christopher J. O’Donnell ◽

Bruce N. Rogers ◽

Brian S. Bronk ◽

Dianne K. Bryce ◽

Jotham W. Coe ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Cognitive Disorders ◽

Nicotinic Acetylcholine ◽

In Vivo Efficacy

Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B

Acta Pharmacologica Sinica ◽

10.1038/aps.2015.9 ◽

2015 ◽

Vol 36 (7) ◽

pp. 800-812 ◽

Cited By ~ 8

Author(s):

Jing-shu Tang ◽

Bing-xue Xie ◽

Xi-ling Bian ◽

Yu Xue ◽

Ning-ning Wei ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Pharmacological Characterization ◽

In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.110.167072 ◽

2010 ◽

Vol 334 (3) ◽

pp. 863-874 ◽

Cited By ~ 40

Author(s):

John Malysz ◽

David J. Anderson ◽

Jens H. Grønlien ◽

Jianguo Ji ◽

William H. Bunnelle ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Pharmacological Characterization ◽

Efficacy and Safety of the α7-Nicotinic Acetylcholine Receptor Agonist ABT-126 in the Treatment of Cognitive Impairment Associated With Schizophrenia

The Journal of Clinical Psychiatry ◽

10.4088/jcp.16m11162 ◽

2018 ◽

Vol 79 (3) ◽

Cited By ~ 3

Author(s):

George M. Haig ◽

Deli Wang ◽

Jun Zhao ◽

Ahmed A. Othman ◽

Earle E. Bain

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

Efficacy And Safety ◽

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Molecular Medicine ◽

10.1186/s10020-020-00177-z ◽

2020 ◽

Vol 26 (1) ◽

Cited By ~ 2

Author(s):

Ravikumar A. Sitapara ◽

Alex G. Gauthier ◽

Sergio I. Valdés-Ferrer ◽

Mosi Lin ◽

Vivek Patel ◽

...

Keyword(s):

Lung Injury ◽

Acetylcholine Receptor ◽

Receptor Agonist ◽

GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor

International Immunopharmacology ◽

10.1016/j.intimp.2015.10.005 ◽

2015 ◽

Vol 29 (2) ◽

pp. 504-512 ◽

Cited By ~ 17

Author(s):

Ye Yue ◽

Ruoxi Liu ◽

Wenxiang Cheng ◽

Yiping Hu ◽

Jinchao Li ◽

...

Keyword(s):

Signaling Pathway ◽

Acetylcholine Receptor ◽

Inflammatory Cytokine ◽

Cytokine Production ◽

Nicotinic Acetylcholine ◽

Inflammatory Cytokine Production