Effect of mitochondrial complex III inhibitors on the regulation of vascular tone in porcine coronary artery

2021 ◽  
Vol 896 ◽  
pp. 173917
Author(s):  
Mohammed Saarti ◽  
Hani Almukhtar ◽  
Paul A. Smith ◽  
Richard E. Roberts
Keyword(s):  
Coronary Artery ◽  
Vascular Tone ◽  
Complex Iii ◽  
Mitochondrial Complex ◽  
Porcine Coronary Artery ◽  
Regulation Of Vascular Tone

Influence of opioids on the vascular tone of isolated porcine coronary artery segments

2000 ◽  
Vol 44 (9) ◽  
pp. 1134-1137 ◽  
Author(s):  
A. P. Klockgether-Radke ◽  
J. Gravemann ◽  
D. Kettler ◽  
G. Hellige
Keyword(s):  
Coronary Artery ◽  
Vascular Tone ◽  
Porcine Coronary Artery

Characterization of Thromboxane A2/Prostaglandin H2 Receptors in Porcine Coronary Artery -The Inhibitory Effect of a Novel Dibenzoxepin Derivative, KW-3635

1992 ◽  
Vol 67 (05) ◽  
pp. 582-584 ◽  
Author(s):  
Ichiro Miki ◽  
Akio Ishii
Keyword(s):  
Coronary Artery ◽  
Binding Sites ◽  
Thromboxane A2 ◽  
Inhibitory Effect ◽  
Scatchard Analysis ◽  
Single Class ◽  
Porcine Coronary Artery ◽  
Equilibrium Binding ◽  
H2 Receptors

SummaryWe characterized the thromboxane A2/prostaglandin H2 receptors in porcine coronary artery. The binding of [3H]SQ 29,548, a thromboxane A2 antagonist, to coronary arterial membranes was saturable and displaceable. Scatchard analysis of equilibrium binding showed a single class of high affinity binding sites with a dissociation constant of 18.5 ±1.0 nM and the maximum binding of 80.7 ± 5.2 fmol/mg protein. [3H]SQ 29,548 binding was concentration-dependently inhibited by thromboxane A2 antagonists such as SQ 29,548, BM13505 and BM13177 or the thromboxane A2 agonists such as U46619 and U44069. KW-3635, a novel dibenzoxepin derivative, concentration-dependently inhibited the [3H]SQ 29,548 binding to thromboxane A2/prosta-glandin H2 receptors in coronary artery with an inhibition constant of 6.0 ± 0.69 nM (mean ± S.E.M.).

Effect of Local Paclitaxel Delivery Following Stenting on Restenosis and Morphology in the Porcine Coronary Artery

2008 ◽  
Vol 2 (1) ◽  
pp. 299-303
Author(s):  
Martin Oberhoff ◽  
Matthias Lerch ◽  
Christian Herdeg ◽  
Axel Kuttner ◽  
Stephen Schroder ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Porcine Coronary Artery
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