Relative bioavailability of griseofulvin lyophilized dry emulsion tablet vs. immediate release tablet: A single-dose, randomized, open-label, six-period, crossover study in healthy adult volunteers in the fasted and fed states

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2008.07.002 ◽

2008 ◽

Vol 35 (3) ◽

pp. 219-225 ◽

Author(s):

Iman Saad Ahmed ◽

Mona Hassan Aboul-Einien ◽

Osama Hussein Mohamed ◽

Samar Farghali Farid

Keyword(s):

Single Dose ◽

Crossover Study ◽

Healthy Adult ◽

Immediate Release ◽

Relative Bioavailability ◽

Dry Emulsion ◽

Adult Volunteers ◽

Download Full-text

Pharmacokinetic properties of fentanyl effervescent buccal tablets: A phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 μg in healthy adult volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2006.05.015 ◽

2006 ◽

Vol 28 (5) ◽

pp. 707-714 ◽

Author(s):

Mona Darwish ◽

Mary Kirby ◽

Philmore Robertson ◽

William Tracewell ◽

John G. Jiang

Keyword(s):

Single Dose ◽

Phase I ◽

Crossover Study ◽

Healthy Adult ◽

Pharmacokinetic Properties ◽

Buccal Tablets ◽

Adult Volunteers

Download Full-text

Dose Proportionality and the Effects of Food on Bioavailability of an Immediate-Release Oxycodone Hydrochloride Tablet Designed to Discourage Tampering and Its Relative Bioavailability Compared With a Marketed Oxycodone Tablet Under Fed Conditions: A Single-Dose, Randomized, Open-Label, 5-Way Crossover Study in Healthy Volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2012.05.009 ◽

2012 ◽

Vol 34 (7) ◽

pp. 1601-1612 ◽

Author(s):

Almasa Bass ◽

Jeffrey G. Stark ◽

Glenn C. Pixton ◽

Kenneth W. Sommerville ◽

Cynthia A. Zamora ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Healthy Volunteers ◽

Immediate Release ◽

Relative Bioavailability ◽

Dose Proportionality ◽

Oxycodone Hydrochloride

Download Full-text

Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1080 pg versus Oral transmucosal fentanyl citrate 1600 pg and dose proportionality of FEBT 270 to 1300 μg: A single-dose, randomized, open-label, three-period study in healthy adult volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2006.05.016 ◽

2006 ◽

Vol 28 (5) ◽

pp. 715-724 ◽

Author(s):

Mona Darwish ◽

Kenneth Tempero ◽

Mary Kirby ◽

Jeffrey Thompson

Keyword(s):

Single Dose ◽

Healthy Adult ◽

Relative Bioavailability ◽

Dose Proportionality ◽

Fentanyl Citrate ◽

Oral Transmucosal Fentanyl Citrate ◽

Buccal Tablet ◽

Adult Volunteers

Download Full-text

Relative bioavailability of tizanidine hydrochloride capsule formulation compared with capsule contents administered in applesauce: A single-dose, open-label, randomized, two-way, crossover study in fasted healthy adult subjects

Clinical Therapeutics ◽

10.1016/j.clinthera.2008.12.014 ◽

2008 ◽

Vol 30 (12) ◽

pp. 2263-2271 ◽

Author(s):

Herbert R. Henney ◽

Anthony Fitzpatrick ◽

Johnston Stewart ◽

Jacob D. Runyan

Keyword(s):

Single Dose ◽

Crossover Study ◽

Healthy Adult ◽

Relative Bioavailability ◽

Capsule Formulation

Download Full-text

Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults

Clinical Therapeutics ◽

10.1016/j.clinthera.2013.03.007 ◽

2013 ◽

Vol 35 (5) ◽

pp. 604-611 ◽

Author(s):

David J. Greenblatt ◽

Jerold S. Harmatz ◽

Thomas Roth ◽

Nikhilesh N. Singh ◽

Margaret L. Moline ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Immediate Release ◽

Healthy Adults ◽

Single Center ◽

Sublingual Tablet ◽

Pharmacokinetic Profiles ◽

Download Full-text

Relative bioavailability of two formulations of nevirapine 200-mg tablets in healthy Chinese male volunteers: A single-dose, randomized-sequence, open-label, two-way crossover study

Clinical Therapeutics ◽

10.1016/s0149-2918(10)80028-1 ◽

2010 ◽

Vol 32 (13) ◽

pp. 2258-2264 ◽

Author(s):

Yubing Zhu ◽

Qian Zhang ◽

Cuixia Yu ◽

Jianjun Zou ◽

Xiaohong Yang ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Relative Bioavailability ◽

Male Volunteers ◽

Healthy Chinese ◽

Download Full-text

Bioequivalence evaluation of two capsule formulations of amoxicillin in healthy adult male bangladeshi volunteers: A single-dose, randomized, open-label, two-period crossover study

Current Therapeutic Research ◽

10.1016/s0011-393x(09)00002-2 ◽

2008 ◽

Vol 69 (6) ◽

pp. 504-513 ◽

Author(s):

Ashik Ullah ◽

Mohammad Abul Kalam Azad ◽

Rebeka Sultana ◽

Maruf Mohammad Akbor ◽

Ahasanul Hasan ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Healthy Adult ◽

Healthy Adult Male

Download Full-text

Relative bioavailability and pharmacokinetic properties of two different enteric formulations of esomeprazole in healthy bangladeshi male volunteers: An open-label, single-dose, randomized-sequence, two-way crossover study

Clinical Therapeutics ◽

10.1016/j.clinthera.2010.07.007 ◽

2010 ◽

Vol 32 (7) ◽

pp. 1419-1426 ◽

Author(s):

Md. Ashik Ullah ◽

Shams-Ud-Dowla ◽

Abdullah Al Maruf ◽

Mohammad Abul Kalam Azad ◽

Md. Hasanuzzaman Shohag ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Relative Bioavailability ◽

Male Volunteers ◽

Pharmacokinetic Properties

Download Full-text

The relative bioavailability and fasting pharmacokinetics of three formulations of olmesartan medoxomil 20-mg capsules and tablets in healthy Chinese male volunteers: An open-label, randomized-sequence, single-dose, three-way crossover study

Clinical Therapeutics ◽

10.1016/j.clinthera.2010.08.004 ◽

2010 ◽

Vol 32 (9) ◽

pp. 1674-1680 ◽

Author(s):

Kun-Yan Li ◽

Jian-Ping Liang ◽

Bing-Qiang Hu ◽

Yu Qiu ◽

Chen-Hui Luo ◽

...

Keyword(s):

Single Dose ◽

Crossover Study ◽

Olmesartan Medoxomil ◽

Relative Bioavailability ◽

Male Volunteers ◽

Healthy Chinese ◽

Download Full-text

Influence of Enteral Feedings on Phenytoin Sodium Absorption from Capsules

Drug Intelligence & Clinical Pharmacy ◽

10.1177/106002808802200205 ◽

1988 ◽

Vol 22 (2) ◽

pp. 130-133 ◽

Author(s):

Lyn Y. Nishimura ◽

Edward P. Armstrong ◽

Patricia M. Plezia ◽

Robert P. Iacono

Keyword(s):

Single Dose ◽

Healthy Adult ◽

Relative Bioavailability ◽

Sodium Absorption ◽

Crossover Fashion ◽

Phenytoin Sodium ◽

Enteral Feedings ◽

Blood Specimens ◽

Adult Volunteers

The influence of enteral feedings (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUCo-48) were not significantly different between the two phases (p > 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.

Download Full-text