scholarly journals An Automated Cocktail Method for In Vitro Assessment of Direct and Time-Dependent Inhibition of Nine Major Cytochrome P450 Enzymes – Application to Establishing CYP2C8 Inhibitor Selectivity

2021 ◽  
pp. 105810
Author(s):  
Helinä Kahma ◽  
Laura Aurinsalo ◽  
Mikko Neuvonen ◽  
Jani Katajamäki ◽  
Marie-Noëlle Paludetto ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Dependent Inhibition ◽  
Inhibitor Selectivity ◽  
In Vitro Assessment ◽  
Time Dependent Inhibition

Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

2012 ◽  
Vol 40 (12) ◽  
pp. 2289-2296 ◽  
Author(s):  
Phillip Yates ◽  
Heather Eng ◽  
Li Di ◽  
R. Scott Obach
Keyword(s):  
Cytochrome P450 ◽  
Statistical Methods ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Integrated in Silico−in Vitro Strategy for Addressing Cytochrome P450 3A4 Time-Dependent Inhibition

2010 ◽  
Vol 23 (3) ◽  
pp. 664-676 ◽  
Author(s):  
Michael Zientek ◽  
Chad Stoner ◽  
Robyn Ayscue ◽  
Jacquelyn Klug-McLeod ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
In Silico ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

A3 - A High-throughput double cocktail approach for evaluating time-dependent inhibition of nine major human cytochrome P450 enzymes

2020 ◽  
Vol 35 (1) ◽  
pp. S19
Author(s):  
Helinä Kahma ◽  
Laura Aurinsalo ◽  
Mikko Neuvonen ◽  
Jenni Viinamäki ◽  
Terhi Launiainen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
High Throughput ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Human Cytochrome ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition ◽  
Cocktail Approach

scholarly journals In vitro screening of reversible and time-dependent inhibition on CYP3A by TM208 and TM209 in rat liver microsomes

2012 ◽  
Vol 2 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Miaoran Ning ◽  
Liang Li ◽  
Jian Li ◽  
Zaiquan Li ◽  
Runtao Li ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Time Dependent ◽  
Rat Liver Microsomes ◽  
In Vitro Screening ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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