scholarly journals An Automated Cocktail Method for In Vitro Assessment of Direct and Time-Dependent Inhibition of Nine Major Cytochrome P450 Enzymes – Application to Establishing CYP2C8 Inhibitor Selectivity

2021 ◽  
pp. 105810
Author(s):  
Helinä Kahma ◽  
Laura Aurinsalo ◽  
Mikko Neuvonen ◽  
Jani Katajamäki ◽  
Marie-Noëlle Paludetto ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Dependent Inhibition ◽  
Inhibitor Selectivity ◽  
In Vitro Assessment ◽  
Time Dependent Inhibition

Integrated in Silico−in Vitro Strategy for Addressing Cytochrome P450 3A4 Time-Dependent Inhibition

2010 ◽  
Vol 23 (3) ◽  
pp. 664-676 ◽  
Author(s):  
Michael Zientek ◽  
Chad Stoner ◽  
Robyn Ayscue ◽  
Jacquelyn Klug-McLeod ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
In Silico ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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