Integrated in Silico−in Vitro Strategy for Addressing Cytochrome P450 3A4 Time-Dependent Inhibition

2010 ◽  
Vol 23 (3) ◽  
pp. 664-676 ◽  
Author(s):  
Michael Zientek ◽  
Chad Stoner ◽  
Robyn Ayscue ◽  
Jacquelyn Klug-McLeod ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
In Silico ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

scholarly journals Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles

2020 ◽  
Vol 48 (6) ◽  
pp. 508-514
Author(s):  
John T. Barr ◽  
Zhican Wang ◽  
Xiaoshan Min ◽  
Henry J. Wienkers ◽  
Brooke M. Rock ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Mechanistic Studies ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

2018 ◽  
Vol 61 (23) ◽  
pp. 10700-10708 ◽  
Author(s):  
Mihirbaran Mandal ◽  
Kaushik Mitra ◽  
Diane Grotz ◽  
Xinjie Lin ◽  
Jairam Palamanda ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput Screening of Cytochrome P450 3A4 Inhibition

2009 ◽  
Vol 24 (6) ◽  
pp. 500-510 ◽  
Author(s):  
Nobuo Sekiguchi ◽  
Atsuko Higashida ◽  
Motohiro Kato ◽  
Yoshiaki Nabuchi ◽  
Tetsuya Mitsui ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
High Throughput ◽  
High Throughput Screening ◽  
Time Dependent ◽  
Cytochrome P450 3A4 ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition

Development and validation of an in vitro, seven-in-one human cytochrome P450 assay for evaluation of both direct and time-dependent inhibition

2016 ◽  
Vol 77 ◽  
pp. 66-75 ◽  
Author(s):  
Dominik Dahlinger ◽  
Sabrina Duechting ◽  
Daniela Nuecken ◽  
Konrad Sydow ◽  
Uwe Fuhr ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Time Dependent ◽  
Human Cytochrome ◽  
Dependent Inhibition ◽  
Development And Validation ◽  
Time Dependent Inhibition

Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis

2015 ◽  
Vol 43 (12) ◽  
pp. 1891-1904 ◽  
Author(s):  
Kaisa A. Salminen ◽  
Minna Rahnasto-Rilla ◽  
Raija Väänänen ◽  
Peter Imming ◽  
Achim Meyer ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Analysis ◽  
Time Dependent ◽  
Isoquinoline Alkaloids ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition ◽  
Silico Analysis

Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

2012 ◽  
Vol 40 (12) ◽  
pp. 2289-2296 ◽  
Author(s):  
Phillip Yates ◽  
Heather Eng ◽  
Li Di ◽  
R. Scott Obach
Keyword(s):  
Cytochrome P450 ◽  
Statistical Methods ◽  
Time Dependent ◽  
Cytochrome P450 Enzymes ◽  
Dependent Inhibition ◽  
Time Dependent Inhibition
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