Primary malignant transformation of giant cell tumor of bone

2007 ◽  
Vol 62 (3) ◽  
pp. 89-93 ◽  
Author(s):  
Eric J. Heffernan ◽  
Paul J. O'Sullivan ◽  
Manoochehr Adibeig ◽  
Luck J. Louis ◽  
Anthony G. Ryan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor

Malignant Transformation of Giant Cell Tumor Affecting the Lower Lip

2015 ◽  
Vol 120 (2) ◽  
pp. e68
Author(s):  
JORGE ESQUICHE LEÓN ◽  
LUCIANA YAMAMOTO DE ALMEIDA ◽  
MARISOL MARTÍNEZ MARTÍNEZ ◽  
FERNANDA DOS SANTOS MOREIRA ◽  
ALÍCIA RUMAYOR PIÑA ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor ◽  
Lower Lip

Malignant Transformation of a Giant Cell Tumor of Bone Treated with Denosumab

2016 ◽  
Vol 6 (3) ◽  
pp. e78 ◽  
Author(s):  
Andrew Park ◽  
Cara A. Cipriano ◽  
Kirk Hill ◽  
Michael Kyriakos ◽  
Douglas J. McDonald
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor

scholarly journals Secondary Malignant Transformation of Giant Cell Tumor of Bone: Is It a Fate?

2019 ◽  
Vol 14 (02) ◽  
pp. 165-174
Author(s):  
Sajjadeh Movahedinia ◽  
◽  
Tina Shooshtarizadeh ◽  
Hassan Mostafavi ◽  
◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor

Malignant Transformation of a Giant Cell Tumor 25 Years After Initial Treatment

2000 ◽  
Vol 381 ◽  
pp. 185-191 ◽  
Author(s):  
Yoshihiko Mori ◽  
Hiroyuki Tsuchiya ◽  
Michiaki Karita ◽  
Akitaka Nonomura ◽  
Takayuki Nojima ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Initial Treatment ◽  
Cell Tumor

scholarly journals Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Cory Julian Broehm ◽  
Erika L. Garbrecht ◽  
Jeff Wood ◽  
Therese Bocklage
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Radiation Treatment ◽  
Cell Tumor ◽  
Rank Ligand ◽  
Review Of The Literature ◽  
Sarcomatous Transformation ◽  
History Of ◽  
Multiple Recurrences

Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence. Sarcomatous transformation is rare and typically occurs with a history of recurrences and radiation treatment. Denosumab, an inhibitor of the RANK ligand involved in bone resorption in GCT, is increasingly used in treatment of recurrent or unresectable giant cell tumor of bone. We report two cases of sarcomatous transformation of GCT to osteosarcoma in patients receiving denosumab. One was a 59-year-old male with a 12-year history of GCT and multiple recurrences taking denosumab for 2.5 years. The second case was in a 56-year-old male with a seven-year history of GCT taking denosumab for six months. Review of the literature shows one case report of malignant transformation of GCT in a patient being treated with denosumab. As the use of denosumab for treatment of GCT will likely increase, larger, controlled studies are needed to ascertain whether denosumab may play a role in malignant transformation of giant cell tumor of bone.

Late Malignant Transformation of Giant Cell Tumor of Bone 41 Years After Primary Surgery

Orthopedics ◽  
2012 ◽  
Vol 35 (10) ◽  
pp. e1566-e1570 ◽  
Author(s):  
Masaru Kadowaki ◽  
Soichiro Yamamoto ◽  
Yuji Uchio
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor ◽  
Primary Surgery

CCND1 and MET Genomic Amplification During Malignant Transformation of a Giant Cell Tumor of Bone

2011 ◽  
Vol 29 (4) ◽  
pp. e86-e89 ◽  
Author(s):  
Esma Saâda ◽  
Michel Peoc'h ◽  
Anne-Valérie Decouvelaere ◽  
Olivier Collard ◽  
Annie-Claude Peyron ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor ◽  
Genomic Amplification

Late Malignant Transformation of a Benign Giant-Cell Tumor of Bone. A Case Report*

1997 ◽  
Vol 79 (2) ◽  
pp. 259-62 ◽  
Author(s):  
R. J. B. SAKKERS ◽  
R. O. VAN DER HEUL ◽  
H. M. KROON ◽  
A. H. M. TAMINIAU ◽  
P. C. W. HOGENDOORN
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor
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