scholarly journals Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Cory Julian Broehm ◽  
Erika L. Garbrecht ◽  
Jeff Wood ◽  
Therese Bocklage
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Radiation Treatment ◽  
Cell Tumor ◽  
Rank Ligand ◽  
Review Of The Literature ◽  
Sarcomatous Transformation ◽  
History Of ◽  
Multiple Recurrences

Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm of bone, with a propensity for recurrence. Sarcomatous transformation is rare and typically occurs with a history of recurrences and radiation treatment. Denosumab, an inhibitor of the RANK ligand involved in bone resorption in GCT, is increasingly used in treatment of recurrent or unresectable giant cell tumor of bone. We report two cases of sarcomatous transformation of GCT to osteosarcoma in patients receiving denosumab. One was a 59-year-old male with a 12-year history of GCT and multiple recurrences taking denosumab for 2.5 years. The second case was in a 56-year-old male with a seven-year history of GCT taking denosumab for six months. Review of the literature shows one case report of malignant transformation of GCT in a patient being treated with denosumab. As the use of denosumab for treatment of GCT will likely increase, larger, controlled studies are needed to ascertain whether denosumab may play a role in malignant transformation of giant cell tumor of bone.

scholarly journals Benign giant cell tumor of bone with pulmonary metastasis- report of two cases and review of literature

2017 ◽  
Vol 5 (3) ◽  
pp. 1131
Author(s):  
Geethu G. Nair ◽  
Rajan G. ◽  
Supriya N. K. ◽  
Sathi P. P.
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pulmonary Metastasis ◽  
Past History ◽  
Bone Lesion ◽  
Giant Cells ◽  
Tumor Location ◽  
Cell Tumor ◽  
Sarcomatous Transformation ◽  
History Of

Tumors that are metastasizing generally considered as malignant. But there are exceptions. Giant cell tumor of bone is well known for its potential to metastasize without sarcomatous transformation. Potential of benign GCT to metastasize was first reported by Jaffe et al in 1940. Prevalence of pulmonary metastasis in benign GCT is between 1-9%. Factors favoring metastasis include recurrence of tumor, surgical manipulation of initial bone tumor, location of femur etc. Peripheral or basilar portion of pulmonary parenchyma is involved commonly. Eventhough death reported in 16-25% of cases, overall it has a favorable prognosis. Surgical resection is preferred treatment for pulmonary metastasis. In the present study 2 case studies were done. In 1st study 18 year old female, known case of GCT Lt tibia, with history of curetting and cementing presented with pain and swelling at same site and pulmonary metastasis 1 year later. Biopsy from initial as well as recurrent tumor confirmed benign GCT without any features of atypia, mitosis or necrosis. Aspirate from pulmonary lesion showed osteoclastic giant cells. No treatment given to metastatic deposits and is asymptomatic even though size of pulmonary lesions is increasing. And in second study a 22 year old female, with past history of GCT referred to our institution for evaluation of lung lesion detected in X-ray. Patient underwent metastatectomy here and histopathology was similar to that of bone lesion. There was no evidence of sarcomatous transformation both in initial and recurrent lesion. Patient is asymptomatic other wise and doing well.

Metastasis of Giant Cell Tumor to the Breast: Case Report and Review of the Literature

2006 ◽  
Vol 92 (4) ◽  
pp. 351-353 ◽  
Author(s):  
Ahmet Alacacıoğblu ◽  
Göksel Bengi ◽  
İıhan Öztop ◽  
Tülay Canda ◽  
Pınar Baicı ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Review Of The Literature

scholarly journals Soft tissue giant cell tumor of low malignant potential of the neck: a case report and review of the literature

2014 ◽  
Vol 30 (1) ◽  
pp. 73 ◽  
Author(s):  
Aylin Orgen Calli ◽  
Mine Tunakan ◽  
Huseyin Katilmis ◽  
Sevil Kilciksiz ◽  
Sedat Ozturkcan
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Potential ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Low Malignant Potential

Giant cell tumor of fifth lumbar vertebrae: two case reports and review of the literature

2007 ◽  
Vol 7 (4) ◽  
pp. 499-505 ◽  
Author(s):  
Yoichi Shimada ◽  
Michio Hongo ◽  
Naohisa Miyakoshi ◽  
Yuji Kasukawa ◽  
Shigeru Ando ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Case Reports ◽  
Lumbar Vertebrae ◽  
Cell Tumor ◽  
Review Of The Literature

Malignant Transformation of Giant Cell Tumor Affecting the Lower Lip

2015 ◽  
Vol 120 (2) ◽  
pp. e68
Author(s):  
JORGE ESQUICHE LEÓN ◽  
LUCIANA YAMAMOTO DE ALMEIDA ◽  
MARISOL MARTÍNEZ MARTÍNEZ ◽  
FERNANDA DOS SANTOS MOREIRA ◽  
ALÍCIA RUMAYOR PIÑA ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor ◽  
Lower Lip

Primary malignant transformation of giant cell tumor of bone

2007 ◽  
Vol 62 (3) ◽  
pp. 89-93 ◽  
Author(s):  
Eric J. Heffernan ◽  
Paul J. O'Sullivan ◽  
Manoochehr Adibeig ◽  
Luck J. Louis ◽  
Anthony G. Ryan ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Malignant Transformation ◽  
Cell Tumor

scholarly journals Giant cell tumor formation due to metallosis after open latarjet and partial shoulder resurfacing

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Matthew Wolfson ◽  
Patrick Curtin ◽  
Emily J. Curry ◽  
Sandra Cerda ◽  
Xinning Li
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Shoulder Arthroplasty ◽  
Total Shoulder Arthroplasty ◽  
Tumor Formation ◽  
Cell Tumor ◽  
History Of ◽  
Pectoralis Major Transfer ◽  
Post Traumatic ◽  
Traumatic Arthritis

Shoulder metallosis with giant cell tumor formation is rarely seen in shoulder surgery. With an increase in shoulder arthroplasty and complex revision shoulder surgeries, clinicians should have an index of suspicion for possible metallosis in patients that presents with unexplained persistent pain with metal components on both the glenoid and humeral side. This case describes a 43-yearold female with a history of six prior shoulder surgeries who presented with shoulder metallosis and giant cell tumor formation after a screw from her open Latarjet procedure began rubbing against her Hemicap implant. She successfully underwent a revision total shoulder arthroplasty for post traumatic arthritis with pectoralis major transfer for her chronic subscapularis rupture and had complete symptom resolution.

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