In vitro inhalation bioaccessibility for particle-bound hydrophobic organic chemicals: Method development, effects of particle size and hydrophobicity, and risk assessment

2018 ◽  
Vol 120 ◽  
pp. 295-303 ◽  
Author(s):  
Shan-Yi Xie ◽  
Jia-Yong Lao ◽  
Chen-Chou Wu ◽  
Lian-Jun Bao ◽  
Eddy Y. Zeng
Keyword(s):  
Risk Assessment ◽  
Particle Size ◽  
Method Development ◽  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals

In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals

2017 ◽  
Vol 36 (7) ◽  
pp. 1934-1946 ◽  
Author(s):  
Yung-Shan Lee ◽  
Justin C. Lo ◽  
S.Victoria Otton ◽  
Margo M. Moore ◽  
Chris J. Kennedy ◽  
...  
Keyword(s):  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
In Vivo Extrapolation

scholarly journals TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

2018 ◽  
Vol 10 (36) ◽  
pp. 4394-4403 ◽  
Author(s):  
Hannah Schug ◽  
Frédéric Begnaud ◽  
Christian Debonneville ◽  
Fabienne Berthaud ◽  
Sylvia Gimeno ◽  
...  
Keyword(s):  
Fish Cell ◽  
Organic Chemicals ◽  
Hydrophobic Organic Chemicals ◽  
New Device

Being able to quantify transfer of compounds across cellular barriers is important but challenging.

Formulation and Evaluation of Mefloquine Hydrochloride Nanoparticles

2014 ◽  
Vol 7 (1) ◽  
pp. 2377-2386
Author(s):  
Dilip Kumar Gupta ◽  
B K Razdan ◽  
Meenakshi Bajpai
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Taste Masking ◽  
Diffusion Method ◽  
Drug Entrapment Efficiency ◽  
Resistant Strains ◽  
Vitro Release

The present study deals with the formulation and evaluation of mefloquine hydrochloride nanoparticles. Mefloquine is a blood schizonticidal quinoline compound, which is indicated for the treatment of mild-to-moderate acute malarial infections caused by mefloquine-susceptible multi-resistant strains of P. falciparum and P. vivax. The purpose of the present work is to minimize the dosing frequency, taste masking toxicity and to improve the therapeutic efficacy by formulating mefloquine HCl nanoparticles. Mefloquine nanoparticles were formulated by emulsion diffusion method using polymer poly(ε-caprolactone) with six different formulations. Nanoparticles were characterized by determining its particle size, polydispersity index, drug entrapment efficiency, drug content, particle morphological character and drug release. The particle size ranged between 100 nm to 240 nm. Drug entrapment efficacy was >95%. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of mefloquine HCl from nanoparticles up to 24 hrs. The results showed that nanoparticles can be a promising drug delivery system for sustained release of mefloquine HCl.

Sign in / Sign up

Export Citation Format

Share Document