Are styrene oligomers in coastal sediments of an industrial area aryl hydrocarbon-receptor agonists?

2016 ◽  
Vol 213 ◽  
pp. 913-921 ◽  
Author(s):  
Seongjin Hong ◽  
Junghyun Lee ◽  
Changkeun Lee ◽  
Seo Joon Yoon ◽  
Seungyeon Jeon ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Industrial Area ◽  
Coastal Sediments ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon

EFFECT OF ARYL HYDROCARBON RECEPTOR AGONISTS AND LIPOPOLYSACCHARIDE ON BENZO(A)PYRENE GENOTOXICITY MARKERS

2019 ◽  
pp. 19-25 ◽  
Author(s):  
V. N. Babakov ◽  
N. Yu. Rogovskaya ◽  
I. D. Kurdyukov ◽  
P. P. Beltyukov ◽  
S. A. Dulov ◽  
...  
Keyword(s):  
Dna Repair ◽  
Aryl Hydrocarbon Receptor ◽  
P53 Protein ◽  
Control Level ◽  
Repair System ◽  
Human Hepatoma Cells ◽  
Kinase Activation ◽  
Receptor Agonists ◽  
Checkpoint Kinases ◽  
Aryl Hydrocarbon

The effect of aryl hydrocarbon receptor agonists (FICZ and ITE), as well as lipopolysaccharide under the toxic action of benzo(a)pyrene in HepaRG human hepatoma cells was evaluated. Active forms of the key stress-activated kinase cascades and DNA repair system proteins were used as markers of the genotoxic action of benzo(a)pyrene. A mixture of lipopolysaccharide with benzo(a)pyrene increases benzo(a)pyrene cytotoxicity and reduces the activation of DNA repair system proteins below the control level. Aryl hydrocarbon receptor agonists (FICZ and ITE) exhibit a cytoprotective effect against benzo(a) pyrene, enhance Akt1 kinase activation, and downregulate activation of the p53 protein and Chk1 and Chk2 checkpoint kinases. Thus, FICZ and ITE reduce the genotoxicity of benzo(a)pyrene.

scholarly journals Lineage‐dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

Hepatology ◽  
2015 ◽  
Vol 61 (2) ◽  
pp. 548-560 ◽  
Author(s):  
Joshua A. Harrill ◽  
Bethany B Parks ◽  
Eliane Wauthier ◽  
J. Craig Rowlands ◽  
Lola M. Reid ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon

scholarly journals Characterization of aryl hydrocarbon receptor agonists in sediments of Wenyu River, Beijing, China

2009 ◽  
Vol 43 (9) ◽  
pp. 2441-2448 ◽  
Author(s):  
Jianping Luo ◽  
Mei Ma ◽  
Jinmiao Zha ◽  
Zijian Wang
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon ◽  
Beijing China

Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists

2020 ◽  
Vol 33 (3) ◽  
pp. 742-750
Author(s):  
Patrick Tarnow ◽  
Catrin Zordick ◽  
Alex Bottke ◽  
Berit Fischer ◽  
Friederike Kühne ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon ◽  
Quinoline Yellow

Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression

Toxicology ◽  
2014 ◽  
Vol 325 ◽  
pp. 31-41 ◽  
Author(s):  
Sebastian Vaas ◽  
Luisa Kreft ◽  
Michael Schwarz ◽  
Albert Braeuning
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon
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