Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride

2014 ◽  
Vol 38 (3) ◽  
pp. 901-912 ◽  
Author(s):  
Wei Guo ◽  
Xiaowei Shi ◽  
Wei Wang ◽  
Weili Zhang ◽  
Junxia Li
Keyword(s):  
Cytochrome P450 ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Rat Liver ◽  
Channel Blocker ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome

In vitro effect of mPEG2k-PCLx micelles on rat liver cytochrome P450 enzymes

2018 ◽  
Vol 552 (1-2) ◽  
pp. 99-110 ◽  
Author(s):  
Lihui Qiu ◽  
Qian Li ◽  
Jiangeng Huang ◽  
Qi Wu ◽  
Kun Tu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome ◽  
Vitro Effect

Inhibitory Mechanisms of Myricetin on Human and Rat Liver Cytochrome P450 Enzymes

2019 ◽  
Vol 44 (5) ◽  
pp. 611-618 ◽  
Author(s):  
Dan Lou ◽  
Su-su Bao ◽  
Ying-hui Li ◽  
Qian-meng Lin ◽  
Su-fen Yang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome ◽  
Inhibitory Mechanisms

Changes in rat liver cytochrome P450 enzymes by atrazine and simazine treatment

Xenobiotica ◽  
1998 ◽  
Vol 28 (7) ◽  
pp. 683-698 ◽  
Author(s):  
N. HANIOKA ◽  
H. JINNO ◽  
T. TANAKA-KAGAWA ◽  
T. NISHIMURA ◽  
M. ANDO
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome

scholarly journals Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro

2008 ◽  
Vol 29 (3) ◽  
pp. 376-384 ◽  
Author(s):  
Dian-lei WANG ◽  
Yan LIANG ◽  
Wei-dong CHEN ◽  
Lin XIE ◽  
Guang-ji WANG ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Ginkgolide B ◽  
Cytochrome P450 Enzymes ◽  
Liver Cytochrome

scholarly journals Changes In Liver and Brain Cytochrome P450 after Multiple Cocaine Administration, Alone and in Combination with Nifedipine

2007 ◽  
Vol 58 (3) ◽  
pp. 287-291 ◽  
Author(s):  
Vessela Vitcheva ◽  
Mitka Mitcheva
Keyword(s):  
Cytochrome P450 ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Wistar Rats ◽  
Channel Blocker ◽  
Cocaine Administration ◽  
Multiple Administration ◽  
Brain Microsomes ◽  
Male Wistar Rats ◽  
The Brain

Changes In Liver and Brain Cytochrome P450 after Multiple Cocaine Administration, Alone and in Combination with NifedipineThe objective of this study was to evaluate possible changes caused by multiple cocaine administration, alone and in combination with 1,4-dihydropiridine calcium channel blocker nifedipine, on cytochrome P450 levels both in the brain and liver. The experiment was done on male Wistar rats divided in four groups: control, treated with nifedipine (5 mg kg-1 i.p. for five days), treated with cocaine (15 mg kg-1 i.p. for five days), and treated with nifedipine and 30 minutes later with cocaine (also for five days). Total cytochrome P450 was measured spectrometrically in liver and brain microsomes. Multiple administration of cocaine alone and in combination with nifedipine did not change the brain P450 significantly. In the liver, nifedipine significantly increased P450 by 28 % vs. control. In contrast, cocaine significantly decreased P450 by 17 % vs. control. In animals treated with nifedipine and cocaine, cytochrome P450 increased 11 % (p<0.01) vs. control, decreased 12.5 % (p<0.001) vs. nifedipine group and increased 34 % (p<0.0001) vs. cocaine group. These results suggest that the cocaine and nifedipine interact at the metabolic level.

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