MATERNAL AND PATERNAL EFFECTS ON OFFSPRING INTERNALISING PROBLEMS: FINDINGS FROM FAMILY DATA AND EXTENDED GCTA ANALYSES

2019 ◽  
Vol 29 ◽  
pp. S16-S17
Author(s):  
Eshim Shahid ◽  
Espen Eilertsen ◽  
Anke Hammerschlag ◽  
Hannah Sallis ◽  
Zhen Qiao ◽  
...  
2010 ◽  
Vol 38 (4) ◽  
pp. 1-9
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  

2020 ◽  
Vol 15 (4) ◽  
pp. 227-262
Author(s):  
Jihong Lee ◽  
Sangdong Kim ◽  
Keunsang Song ◽  
Jangwon Kim
Keyword(s):  

Author(s):  
Aja Louise Murray ◽  
Daniel Nagin ◽  
Ingrid Obsuth ◽  
Denis Ribeaud ◽  
Manuel Eisner

AbstractDevelopmental trajectories of common mental health issues such as ADHD symptoms, internalising problems, and externalising problems can often be usefully summarised in terms of a small number of ‘developmental subtypes’ (e.g., ‘childhood onset’, ‘adolescent onset’) that may differ in their profiles or levels of clinically meaningful variables such as etiological risk factors. However, given the strong tendency for symptoms in these domains to co-occur, it is important to consider not only developmental subtypes in each domain individually, but also the joint developmental subtypes defined by symptoms trajectories in all three domains together (e.g., ‘late onset multimorbid’, ‘pure internalising’, ‘early onset multimorbid’). Previous research has illuminated the joint developmental subtypes of ADHD symptoms, internalising problems, and externalising problems that emerge from normative longitudinal data using methods such as group-based trajectory modelling, as well as predictors of membership in these developmental subtypes. However, information on the long-term outcomes of developmental subtype membership is critical to illuminate the likely nature and intensity of support needs required for individuals whose trajectories fit different developmental subtypes. We, therefore, evaluated the relations between developmental subtypes previously derived using group-based trajectory modelling in the z-proso study (n = 1620 with trajectory data at ages 7, 8, 9, 10, 11, 12, 13, 15) and early adulthood outcomes. Individuals with multimorbid trajectories but not ‘pure’ internalising problem elevations showed higher levels of social exclusion and delinquency at age 20. These associations held irrespective of the specific developmental course of symptoms (e.g., early versus late onset versus remitting). There was also some evidence that intimate partner violence acts as a form of heterotypic continuity for earlier externalising problems. Results underline the need for early intervention to address the pathways that lead to social exclusion and delinquency among young people with multiple co-occurring mental health issues.


1987 ◽  
Vol 4 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Jay H. Lubin ◽  
Sherri J. Bale ◽  
D. C. Rao
Keyword(s):  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alex R. De Serrano ◽  
Kimberly A. Hughes ◽  
F. Helen Rodd

AbstractEvidence is emerging that paternal effects, the nongenetic influence of fathers on their offspring, can be transgenerational, spanning several generations. Methylphenidate hydrochloride (MPH; e.g. Ritalin) is a dopaminergic drug that is highly prescribed to adolescent males for the treatment of Attention-deficit/hyperactivity disorder. It has been suggested that MPH could cause transgenerational effects because MPH can affect the male germline in rodents and because paternal effects have been observed in individuals taking similar drugs (e.g. cocaine). Despite these concerns, the transgenerational effects of paternal MPH exposure are unknown. Therefore, we exposed male and female Trinidadian guppies (Poecilia reticulata) to a low, chronic dose of MPH and observed that MPH affected the anxiety/exploratory behaviour of males, but not females. Because of this male-specific effect, we investigated the transgenerational effects of MPH through the paternal line. We observed behavioural effects of paternal MPH exposure on offspring and great-grandoffspring that were not directly administered the drug, making this the first study to demonstrate that paternal MPH exposure can affect descendants. These effects were not due to differential mortality or fecundity between control and MPH lines. These results highlight the transgenerational potential of MPH.


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