Production and analysis of stable microfluidic devices with tunable surface hydrophilicity via the in-situ tertiary-amine catalyzed Michael addition of a multifunctional thiol to a multifunctional acrylate

2020 ◽  
Vol 126 ◽  
pp. 109482 ◽  
Author(s):  
Jagannath Upadhyay ◽  
Christopher O. Bounds ◽  
Nicholas Totaro ◽  
Suman Thakuri ◽  
Leah Garber ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Microfluidic Devices ◽  
Surface Hydrophilicity

scholarly journals A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst

2020 ◽  
Vol 11 (21) ◽  
pp. 5572-5576 ◽  
Author(s):  
Noboru Hayama ◽  
Yusuke Kobayashi ◽  
Eriko Sekimoto ◽  
Anna Miyazaki ◽  
Kiyofumi Inamoto ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Tertiary Amine ◽  
Michael Addition ◽  
Arylboronic Acid ◽  
Unsaturated Carboxylic Acids

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported.

ent-Kaurane Diterpenoids from Chinese Liverworts and Their Antitumor Activities through Michael Addition As Detected in Situ by a Fluorescence Probe

2015 ◽  
Vol 58 (9) ◽  
pp. 3944-3956 ◽  
Author(s):  
Zhaomin Lin ◽  
Yanxia Guo ◽  
Yanhui Gao ◽  
Shuqi Wang ◽  
Xiaoning Wang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Fluorescence Probe ◽  
Antitumor Activities

Label-free biosensors based on in situ formed and functionalized microwires in microfluidic devices

The Analyst ◽  
2015 ◽  
Vol 140 (23) ◽  
pp. 7896-7901 ◽  
Author(s):  
Yanlong Xing ◽  
Andreas Wyss ◽  
Norbert Esser ◽  
Petra S. Dittrich
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic System ◽  
Label Free ◽  
System P

Label-free biosensors based on in situ formed and functionalized TTF–Au wires were developed using an integrated microfluidic system.

Dearomatization-Rearomatization Strategy of Tyrosine for Peptides/Protein Modification through Thiol-Addition Reactions

2021 ◽  
Author(s):  
Pengxin Wang ◽  
Yulian Cheng ◽  
Chunlei Wu ◽  
Ruixiang Luo ◽  
Caibin Ma ◽  
...  
Keyword(s):  
Michael Addition ◽  
Protein Modification ◽  
Addition Reactions

We have developed a dearomatization-rearomatization strategy for modification of peptides/protein through thiol-Michael addition to the electrophilic cyclohexadienone intermediate in situ generated by oxidation of tyrosine. This strategy enriches the conjugation...

scholarly journals Tertiary amine-catalyzed generation of chlorine dioxide from hypochlorous acid and chlorite ions

2020 ◽  
Author(s):  
Estefania Isaza Ferro ◽  
Jordan Perrin ◽  
Owain George John Dawson ◽  
Tapani Vuorinen
Keyword(s):  
Chlorine Dioxide ◽  
Tertiary Amine ◽  
Hypochlorous Acid ◽  
Suitable Candidate ◽  
Rate Limiting Step ◽  
Limiting Step ◽  
Chlorite Ions ◽  
The Stability ◽  
Rate Limiting

AbstractThe reaction between hypochlorous acid and chlorite ions is the rate limiting step for in situ chlorine dioxide regeneration. The possibility of increasing the speed of this reaction was analyzed by the addition of tertiary amine catalysts in the system at pH 5. Two amines were tested, DABCO (1,4-diazabicyclo[2.2.2]octane) and its derivative CEM-DABCO (1-carboethoxymethyl-1-azonia-4-aza-bicyclo[2.2.2]octane chloride). The stability of the catalysts in the presence of both reagents and chlorine dioxide was measured, with CEM-DABCO showing to be highly stable with the mentioned chlorine species, whereas DABCO was rapidly degraded by chlorine dioxide. Hence, CEM-DABCO was chosen as a suitable candidate to catalyze the reaction of hypochlorous acid with chlorite ions and it significantly increased the speed of this reaction even at low catalyst dosages. This research opens the door to a faster regeneration of chlorine dioxide and an improved efficiency in chlorine dioxide treatments.

Cu-Catalyzed one-pot synthesis of thiochromeno-quinolinone and thiochromeno-thioflavone via oxidative double hetero Michael addition using in situ generated nucleophiles

2020 ◽  
Vol 56 (62) ◽  
pp. 8826-8829
Author(s):  
Nallappan Sundaravelu ◽  
Govindasamy Sekar
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis

A copper catalyzed three-component synthesis of π-conjugated tetracyclic thiochromeno-quinolinone and thiochromeno-thioflavone was established via oxidative double hetero Michael addition using in situ generated nucleophiles.

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