PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis

Experimental Eye Research ◽

10.1016/j.exer.2010.03.002 ◽

2010 ◽

Vol 90 (6) ◽

pp. 718-725 ◽

Author(s):

Zahra Faghiri ◽

Nicolas G. Bazan

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Pigment Epithelial ◽

Neuroprotectin D1 ◽

Induced Apoptosis

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Neuroprotectin D1 Induces Dephosphorylation of Bcl-xLin a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival

Journal of Biological Chemistry ◽

10.1074/jbc.m109.095232 ◽

2010 ◽

Vol 285 (24) ◽

pp. 18301-18308 ◽

Author(s):

Rajee Antony ◽

Walter J. Lukiw ◽

Nicolas G. Bazan

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Dependent Manner ◽

Pigment Epithelial ◽

Neuroprotectin D1

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Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0705949104 ◽

2007 ◽

Vol 104 (32) ◽

pp. 13152-13157 ◽

Author(s):

P. K. Mukherjee ◽

V. L. Marcheselli ◽

S. Barreiro ◽

J. Hu ◽

D. Bok ◽

...

Keyword(s):

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Pigment Epithelial ◽

Neuroprotectin D1

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Neuroprotectin D1 Modulates the Induction of Pro-Inflammatory Signaling and Promotes Retinal Pigment Epithelial Cell Survival DuringOxidative Stress

Retinal Degenerative Diseases - Advances in Experimental Medicine and Biology ◽

10.1007/978-1-4419-1399-9_76 ◽

2009 ◽

pp. 663-670 ◽

Author(s):

Jorgelina M. Calandria ◽

Nicolas G. Bazan

Keyword(s):

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Inflammatory Signaling ◽

Pigment Epithelial ◽

Neuroprotectin D1

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PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

Aging ◽

10.18632/aging.101299 ◽

2017 ◽

Vol 9 (10) ◽

pp. 2052-2068 ◽

Author(s):

Dinusha Rajapakse ◽

Mei Chen ◽

Tim M. Curtis ◽

Heping Xu

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Pigment Epithelial

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Neurotrophins Induce Neuroprotective Signaling in the Retinal Pigment Epithelial Cell by Activating the Synthesis nl of the Anti-inflammatory and Anti-apoptotic Neuroprotectin D1

Advances in Experimental Medicine and Biology - Recent Advances in Retinal Degeneration ◽

10.1007/978-0-387-74904-4_3 ◽

2008 ◽

pp. 39-44 ◽

Author(s):

Nicolas G. Bazan

Keyword(s):

Epithelial Cell ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Pigment Epithelial ◽

Neuroprotectin D1 ◽

Neuroprotective Signaling ◽

Anti Inflammatory

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Inhibition of Sumoylation Alleviates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Represses Proinflammatory Gene Expression

Current Molecular Medicine ◽

10.2174/1566524019666190107154250 ◽

2019 ◽

Vol 18 (9) ◽

pp. 575-583 ◽

Author(s):

Q. Sun ◽

W. Qing ◽

R. Qi ◽

M. Zou ◽

L. Gong ◽

...

Keyword(s):

Oxidative Stress ◽

Gene Expression ◽

Epithelial Cell ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Senescence ◽

Pigment Epithelial ◽

Proinflammatory Gene ◽

Proinflammatory Gene Expression

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Activin A improves retinal pigment epithelial cell survival on stiff but not soft substrates

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.36476 ◽

2018 ◽

Vol 106 (11) ◽

pp. 2871-2880

Author(s):

Corina E. White ◽

Bryan Kwok ◽

Ronke M. Olabisi

Keyword(s):

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Activin A ◽

Pigment Epithelial

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BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

Journal of Biological Chemistry ◽

10.1074/jbc.m809393200 ◽

2009 ◽

Vol 284 (14) ◽

pp. 9529-9539 ◽

Author(s):

DanHong Zhu ◽

Jian Wu ◽

Christine Spee ◽

Stephen J. Ryan ◽

David R. Hinton

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Macular Degeneration ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Senescence ◽

Age Related Macular Degeneration ◽

Pigment Epithelial ◽

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Docosahexaenoic Acid Signalolipidomics in the Homeostatic Modulation of Photoreceptor/Retinal Pigment Epithelial Cell Integrity During Oxidative Stress

Studies on Retinal and Choroidal Disorders ◽

10.1007/978-1-61779-606-7_7 ◽

2012 ◽

pp. 141-163

Author(s):

Nicolas G. Bazan ◽

Anasheh Halabi

Keyword(s):

Oxidative Stress ◽

Epithelial Cell ◽

Docosahexaenoic Acid ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Cell Integrity ◽

Pigment Epithelial

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NPD1 Induction of Retinal Pigment Epithelial Cell Survival Involves PI3K/Akt Phosphorylation Signaling

Neurochemical Research ◽

10.1007/s11064-010-0351-8 ◽

2010 ◽

Vol 35 (12) ◽

pp. 1944-1947 ◽

Author(s):

Natalie A. Halapin ◽

Nicolas G. Bazan

Keyword(s):

Epithelial Cell ◽

Cell Survival ◽

Retinal Pigment Epithelial ◽

Retinal Pigment Epithelial Cell ◽

Retinal Pigment ◽

Akt Phosphorylation ◽

Pigment Epithelial

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