Cotargeting of Bcl-2 and Mcl-1 Shows Promising Antileukemic Activity against AML Cells Including those with Acquired Cytarabine Resistance

2021 ◽  
Author(s):  
Fangbing Liu ◽  
Qiushi Zhao ◽  
Yongwei Su ◽  
Jing Lv ◽  
Yuqing Gai ◽  
...  
Keyword(s):  
Antileukemic Activity

Synthesis and Antileukemic Activity of N-Phthaloyl-2-Aminoalcohols

2004 ◽  
Vol 38 (3) ◽  
pp. 120-122
Author(s):  
A. V. Osintsev ◽  
G. L. Levit ◽  
V. P. Krasnov ◽  
G. D. Miles ◽  
S. Yu. Solodnikov ◽  
...  
Keyword(s):  
Antileukemic Activity

scholarly journals A new one-pot three-component synthesis of 4-aryl-6-cycloamino-1,3,5-triazin-2-amines under microwave irradiation

Synthesis ◽  
2021 ◽  
Author(s):  
Muhammad Syafiq Bin Shahari ◽  
Ahmad Junaid ◽  
Edward R. T. Tiekink ◽  
Anton V. Dolzhenko
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehydes ◽  
Antileukemic Activity ◽  
One Pot ◽  
Biological Screening ◽  
X Ray ◽  
X Ray Crystallography ◽  
Cyclic Amines ◽  
Three Component Reaction ◽  
Fast Synthesis

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) to the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amines. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-(3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)-4-phenyl-1,3,5-triazin-2-amine.

ChemInform Abstract: Cysteine Chloromethyl and Diazomethyl Ketone Derivatives with Potent Antileukemic Activity.

ChemInform ◽  
2010 ◽  
Vol 31 (28) ◽  
pp. no-no
Author(s):  
David A. Perrey ◽  
Rama Krishna Narla ◽  
Fatih M. Uckun
Keyword(s):  
Antileukemic Activity

scholarly journals Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo

2018 ◽  
Vol 148 ◽  
pp. 13-26 ◽  
Author(s):  
Yongwei Su ◽  
Xinyu Li ◽  
Jun Ma ◽  
Jianyun Zhao ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Signaling Network ◽  
Antileukemic Activity
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