scholarly journals Percutaneous flexor digitorum brevis tenotomy: An anatomical study

2021 ◽  
Author(s):  
Paulo Carvalho ◽  
Miki Dalmau-Pastor ◽  
Caroline Lozi ◽  
Matheus Souza ◽  
Julien Lucas-Y-Hernandez ◽  
...  
Keyword(s):  
Anatomical Study ◽  
Flexor Digitorum Brevis ◽  
Flexor Digitorum

scholarly journals Morphology of flexor digitorum brevis muscle in northern Tamil Nadu region-an anatomical study with phylogenetic perspective

2012 ◽  
Vol 01 (03) ◽  
pp. 129-132
Author(s):  
T S Gugapriya
Keyword(s):  
Tamil Nadu ◽  
Anatomical Study ◽  
Erect Posture ◽  
Heel Pad ◽  
Evolutionary Changes ◽  
Male Cadaver ◽  
Flexor Digitorum Brevis ◽  
Phylogenetic Perspective ◽  
Clinically Significant ◽  
Flexor Digitorum

Abstract Background and aims : "Arches of foot" formed by the combination of skeletal and a muscular element is a unique feature of evolution as an adaptation to habitual erect posture in humans. Flexor digitorum brevis (FDB) is the most superficial intrinsic muscle of the sole that present with variations frequently. The objective of this study was to find out the pattern of presentation of FDB in northern Tamil Nadu region. Material and methods: Thirty soles of 12 male and three female embalmed cadavers were dissected and FDB was observed for variations. A comparative analysis was done with previous studies. Results: Twenty five soles showed absence of FDB tendon to little toe. Three soles confirmed to the classical book description. The soles of a 62 years old male cadaver presented with a variation of FDB. It showed a separate deep slip to the 5th toe arising from intermuscular septum and from long flexor tendon with the slip found to get inserted at the base of middle phalanx bilaterally. The incidence of 83.3% absence of FDB tendon to 5th toe in the present study was significantly higher when compared to many previous reports. Conclusion: Variations of FDB are clinically significant because FDB musculocutaneos flap is used in the reconstruction of the heel pad and FDB tendons are used in tendon transfer surgeries for claw or hammer toe deformities. The absence of FDB tendon to the 5th toe shows clustering around Asian region, which signifies possibility of occurrence of evolutionary changes in specific topographic region

scholarly journals An Anatomical Study Of The Musculus Flexor Digitorum Brevis

10.3823/2486 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Humberto Ferreira Arquez
Keyword(s):  
Diagnostic Imaging ◽  
Age Groups ◽  
Anatomical Study ◽  
Anatomical Variations ◽  
Demographic Characteristics ◽  
Foot Surgery ◽  
Flexor Digitorum Brevis ◽  
Flexor Digitorum ◽  
The University

Background: The present study documents valuable new data on the anatomical variations of the musculus flexor digitorum brevis in an adult Colombian population, this muscle and in particular its fourth slip, has a significant clinical and surgical importance. The fourth slip is undergoing a phylogenetic degeneration. The purpose of this study is to conduct an evidenced on the prevalence of the musculus flexor digitorum brevis and its variants in humans. Methods and Findings: A total of 17 cadavers with different age groups were used for this study, 34 feet of 15 male and 2 females embalmed adults cadavers in the laboratory of Morphology of the University of Pamplona. All feet (n= 34) were studied serially during the years 2013-2016. Of the 34 feet examined, in 32 (94.12%) the muscle conformed to the classical descriptions given in anatomical textbooks showed 4 bellies. In the remaining 2 feet (5.88%) the muscle divided into three parts which ended in slender tendons to the second, third and fourth toes. Conclusions: The knowledge of the anatomical variations in relation to the demographic characteristics of patients would be of importance for diagnostic imaging and foot surgery.

scholarly journals Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1791
Author(s):  
Rosa Scala ◽  
Fatima Maqoud ◽  
Nicola Zizzo ◽  
Giuseppe Passantino ◽  
Antonietta Mele ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Katp Channel ◽  
Ex Vivo ◽  
Channel Modulation ◽  
Flexor Digitorum Brevis ◽  
Inflammatory Edema ◽  
Flexor Digitorum ◽  
Channel Currents

(1) Background: Cantu syndrome (CS) arises from gain-of-function (GOF) mutations in the ABCC9 and KCNJ8 genes, which encode ATP-sensitive K+ (KATP) channel subunits SUR2 and Kir6.1, respectively. Most CS patients have mutations in SUR2, the major component of skeletal muscle KATP, but the consequences of SUR2 GOF in skeletal muscle are unknown. (2) Methods: We performed in vivo and ex vivo characterization of skeletal muscle in heterozygous SUR2[A478V] (SUR2wt/AV) and homozygous SUR2[A478V] (SUR2AV/AV) CS mice. (3) Results: In SUR2wt/AV and SUR2AV/AV mice, forelimb strength and diaphragm amplitude movement were reduced; muscle echodensity was enhanced. KATP channel currents recorded in Flexor digitorum brevis fibers showed reduced MgATP-sensitivity in SUR2wt/AV, dramatically so in SUR2AV/AV mice; IC50 for MgATP inhibition of KATP currents were 1.9 ± 0.5 × 10−5 M in SUR2wt/AV and 8.6 ± 0.4 × 10−6 M in WT mice and was not measurable in SUR2AV/AV. A slight rightward shift of sensitivity to inhibition by glibenclamide was detected in SUR2AV/AV mice. Histopathological and qPCR analysis revealed atrophy of soleus and tibialis anterior muscles and up-regulation of atrogin-1 and MuRF1 mRNA in CS mice. (4) Conclusions: SUR2[A478V] “knock-in” mutation in mice impairs KATP channel modulation by MgATP, markedly so in SUR2AV/AV, with atrophy and non-inflammatory edema in different skeletal muscle phenotypes.

Intramuscular Hemangioma of Flexor Digitorum Brevis Muscle

2012 ◽  
Vol 91 (10) ◽  
pp. 910 ◽  
Author(s):  
Mustafa Ozsahin ◽  
Mustafa Uslu ◽  
Erkan Inanmaz ◽  
Ramazan Buyukkaya ◽  
Havva Erdem
Keyword(s):  
Flexor Digitorum Brevis ◽  
Intramuscular Hemangioma ◽  
Flexor Digitorum

scholarly journals Differential impact of mitochondrial positioning on mitochondrial Ca2+ uptake and Ca2+ spark suppression in skeletal muscle

2011 ◽  
Vol 301 (5) ◽  
pp. C1128-C1139 ◽  
Author(s):  
Ann E. Rossi ◽  
Simona Boncompagni ◽  
Lan Wei ◽  
Feliciano Protasi ◽  
Robert T. Dirksen
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Osmotic Shock ◽  
Progressive Increase ◽  
Tetanic Stimulation ◽  
Differential Impact ◽  
Flexor Digitorum Brevis ◽  
Flexor Digitorum ◽  
Activity Dependent ◽  
Old Mice

Muscle contraction requires ATP and Ca2+ and, thus, is under direct control of mitochondria and the sarcoplasmic reticulum. During postnatal skeletal muscle maturation, the mitochondrial network exhibits a shift from a longitudinal (“longitudinal mitochondria”) to a mostly transversal orientation as a result of a progressive increase in mitochondrial association with Ca2+ release units (CRUs) or triads (“triadic mitochondria”). To determine the physiological implications of this shift in mitochondrial disposition, we used confocal microscopy to monitor activity-dependent changes in myoplasmic (fluo 4) and mitochondrial (rhod 2) Ca2+ in single flexor digitorum brevis (FDB) fibers from 1- to 4-mo-old mice. A robust and sustained Ca2+ accumulation in triadic mitochondria was triggered by repetitive tetanic stimulation (500 ms, 100 Hz, every 2.5 s) in FDB fibers from 4-mo-old mice. Specifically, mitochondrial rhod 2 fluorescence increased 272 ± 39% after a single tetanus and 412 ± 45% after five tetani and decayed slowly over 10 min following the final tetanus. Similar results were observed in fibers expressing mitochondrial pericam, a mitochondrial-targeted ratiometric Ca2+ indicator. Interestingly, sustained mitochondrial Ca2+ uptake following repetitive tetanic stimulation was similar for triadic and longitudinal mitochondria in FDB fibers from 1-mo-old mice, and both mitochondrial populations were found by electron microscopy to be continuous and structurally tethered to the sarcoplasmic reticulum. Conversely, the frequency of osmotic shock-induced Ca2+ sparks per CRU density decreased threefold (from 3.6 ± 0.2 to 1.2 ± 0.1 events·CRU−1·min−1·100 μm−2) during postnatal development in direct linear correspondence ( r2 = 0.95) to an increase in mitochondrion-CRU pairing. Together, these results indicate that mitochondrion-CRU association promotes Ca2+ spark suppression but does not significantly impact mitochondrial Ca2+ uptake.

Absence of fourth slip of flexor digitorum brevis in Nepalese population

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
AjayaJang Kunwar ◽  
KrishnaDeo Sharma ◽  
Dhiraj Maskey
Keyword(s):  
Flexor Digitorum Brevis ◽  
Flexor Digitorum
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