A national study of the effect of increasing obesity on the response to and outcome of assisted reproductive technology (ART)

2010 ◽  
Vol 94 (4) ◽  
pp. S52
Author(s):  
B. Luke ◽  
M.B. Brown ◽  
S.A. Missmer ◽  
O. Bukulmez ◽  
R. Leach ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
National Study

scholarly journals Health and development of children born after assisted reproductive technology and sub-fertility compared to naturally conceived children: data from a national study

2014 ◽  
Vol 6 (1) ◽  
Author(s):  
Alastair G. Sutcliffe ◽  
Edward Melhuish ◽  
Jacqueline Barnes ◽  
Julian Gardiner
Keyword(s):  
Assisted Reproductive Technology ◽  
Hospital Admissions ◽  
Reproductive Technology ◽  
National Study ◽  
Control Group ◽  
Deprived Neighborhoods ◽  
National Cohort ◽  
Health And Development ◽  
Matched Case ◽  
Using Data

In a non-matched case-control study using data from two large national cohort studies, we investigated whether indicators of child health and development up to 7 years of age differ between children conceived using assisted reproductive technology (ART), children born after sub-fertility (more than 24 months of trying for conception) and other children. Information on ART use/sub-fertility was available for 23,649 children. There were 227 cases (children conceived through ART) and two control groups: 783 children born to sub-fertile couples, and 22,639 children born to couples with no fertility issues. In models adjusted for social and demographic factors there were significant differences between groups in rate of hospital admissions before the children were 9 months old (P=0.029), with the ART group showing higher rates of hospital admission than the <em>no fertility issues</em> control group, the sub-fertile control group being intermediate between the two. Children born after ART had comparable health and development beyond 9 months of age to their naturally conceived peers. This applied to the whole sample and to a sub-sample of children from deprived neighborhoods.

The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study

2011 ◽  
Vol 96 (4) ◽  
pp. 820-825 ◽  
Author(s):  
Barbara Luke ◽  
Morton B. Brown ◽  
Stacey A. Missmer ◽  
Orhan Bukulmez ◽  
Richard Leach ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
National Study

The role of inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy as a result of ART

2016 ◽  
pp. 73-76
Author(s):  
B.M. Ventskivskiy ◽  
◽  
I.V. Poladych ◽  
S.O. Avramenko ◽  
◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Local Level ◽  
Multiple Pregnancy ◽  
Reproductive Technology ◽  
System Level ◽  
Premature Labor ◽  
Pro Inflammatory Cytokines

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

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