In vitro metabolism in Sprague–Dawley rat liver microsomes of forsythoside A in different compositions of Shuang–Huang–Lian

Fitoterapia ◽  
2011 ◽  
Vol 82 (8) ◽  
pp. 1222-1230 ◽  
Author(s):  
Wei Zhou ◽  
Liu-qing Di ◽  
Jin-jun Shan ◽  
Xiao-lin Bi ◽  
Le-tian Chen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes ◽  
Sprague Dawley ◽  
Sprague Dawley Rat

In vitro metabolism of T-2 toxin by rat liver microsomes

1986 ◽  
Vol 34 (5) ◽  
pp. 865-868 ◽  
Author(s):  
Catherine A. Knupp ◽  
Steven P. Swanson ◽  
William B. Buck
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes

Inhibitory Effect of Resveratrol on the Pharmacokinetics of Ticagrelor in Vivo and Vitro

2021 ◽  
Author(s):  
Peng Wang ◽  
Xiao-Xia Hu ◽  
Ying-hui Li ◽  
Nan-Yong Gao ◽  
Guo-quan Chen ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Study ◽  
Inhibitory Effect ◽  
Control Group ◽  
Rat Liver Microsomes ◽  
Sprague Dawley ◽  
Group B

This study was to evaluate the effect of resveratrol on the pharmacokinetics of ticagrelor in rats and the metabolism of ticagrelor in human CYP3A4 and liver microsomes. Eighteen Sprague-Dawley rats were randomly divided into three groups: group A (control group), group B (50mg/kg resveratrol), and group C (150mg/kg resveratrol ). After 30 minutes administration of resveratrol, a single dose of ticagrelor (18mg/kg) was administered orally. The vitro experiment was performed to examine the influence of resveratrol on ticagrelor metabolism in CYP3A4*1, human, and rat liver microsomes. Serial biological samples were assayed by validated UHPLC-MS/MS methods. In vivo study, the AUC and Cmax of ticagrelor in group B and C appeared to be significantly higher than the control group, while Vz/F and CLz/F of ticagrelor in group B and C were significantly decreased. In vitro study, resveratrol exhibited an inhibitory effect on CYP3A4*1, human and rat liver microsomes. The IC50 values of resveratrol were 56.75μM，69.07μM and 14.22μM, respectively. Our results indicated that resveratrol had a inhibitory effect on the metabolism of ticagrelor in vitro and vivo. It should be paid more attention to the clinical combination of resveratrol with ticagrelor and ticagrelor plasma concentration should be monitored to avoid the occurrence of adverse reaction.

In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities

2014 ◽  
Vol 37 (3) ◽  
pp. 996-1005 ◽  
Author(s):  
Satoko Tange ◽  
Nariaki Fujimoto ◽  
Naoto Uramaru ◽  
Kazumi Sugihara ◽  
Shigeru Ohta ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes ◽  
Cis And Trans

A non-michaelian behavior of the in vitro metabolism of the pentacyclic triterpene alfa and beta amyrins by employing rat liver microsomes

2013 ◽  
Vol 84 ◽  
pp. 14-19 ◽  
Author(s):  
Fernanda de Lima Moreira ◽  
Gustavo Henrique Bianco de Souza ◽  
Ivanildes Vasconcelos Rodrigues ◽  
Norberto Peporine Lopes ◽  
Anderson Rodrigo Moraes de Oliveira
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes ◽  
Pentacyclic Triterpene

scholarly journals In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation

2020 ◽  
Vol 315 ◽  
pp. 108905 ◽  
Author(s):  
Danlei Wang ◽  
Ben Bruyneel ◽  
Lenny Kamelia ◽  
Sebastiaan Wesseling ◽  
Ivonne M.C.M. Rietjens ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Side Chain ◽  
Rat Liver Microsomes ◽  
Alkyl Side Chain

scholarly journals 6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-14C] 6:2 fluorotelomer alcohol

Chemosphere ◽  
2014 ◽  
Vol 112 ◽  
pp. 34-41 ◽  
Author(s):  
Ting Ruan ◽  
Lisa M. Sulecki ◽  
Barry W. Wolstenholme ◽  
Guibin Jiang ◽  
Ning Wang ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes

In vitro metabolism of the alkaloid piplartine by rat liver microsomes

2014 ◽  
Vol 95 ◽  
pp. 113-120 ◽  
Author(s):  
Lucas Maciel Mauriz Marques ◽  
Eduardo Afonso da Silva-Junior ◽  
Dayana Rubio Gouvea ◽  
Ricardo Vessecchi ◽  
Mônica Tallarico Pupo ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes

In vitro metabolism of the anti-androgenic fungicide vinclozolin by rat liver microsomes

2011 ◽  
Vol 86 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Adolfo Sierra-Santoyo ◽  
Esperanza Angeles-Soto ◽  
Ma. de Lourdes López-González ◽  
Randy A. Harrison ◽  
Michael F. Hughes
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
In Vitro Metabolism ◽  
Rat Liver Microsomes
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