Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration

2007 ◽  
Vol 168 (2-3) ◽  
pp. 200-207 ◽  
Author(s):  
L. Lindberg ◽  
S. Brauer ◽  
P. Wollmer ◽  
L. Goldberg ◽  
A.W. Jones ◽  
...  
Keyword(s):  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Blood Alcohol ◽  
Arterial Blood ◽  
Breath Alcohol ◽  
Breath Alcohol Concentration

Accuracy and precision of breath alcohol measurements for subjects in the absorptive state.

1987 ◽  
Vol 33 (6) ◽  
pp. 753-756 ◽  
Author(s):  
G Simpson
Keyword(s):  
Law Enforcement ◽  
Venous Blood ◽  
Blood Alcohol Concentration ◽  
Maximum Error ◽  
Alcohol Concentration ◽  
Published Data ◽  
Blood Alcohol ◽  
Breath Alcohol ◽  
Accuracy And Precision ◽  
Breath Alcohol Concentration

Abstract Published data are analyzed in order to estimate the accuracy of breath-alcohol measurements for subjects during absorption of orally ingested ethanol. Simultaneous measurements of breath alcohol concentration (BrAC) and venous blood alcohol concentration (VBAC) show that actual VBAC can be overestimated by more than 100% for a significant amount of time after drinking stops. The maximum error found for four individual subjects is +230%, +190%, +60%, and +30%. The magnitude of these errors indicates that results from quantitative evidential breath alcohol analyzers are far less accurate for the absorptive state than they are during the postabsorptive state, but the specifications for accuracy and precision given by manufacturers of these instruments do not reflect this. The results also indicate that there is a significant likelihood that subjects will be in the absorptive state when tested under field conditions. I conclude that estimates of BAC based on BrAC measurements are not reliable in the absorptive state and that the uncertainty associated with such estimates should be accounted for, particularly when the results are used in connection with law enforcement.

Correlation between blood alcohol concentration (BAC), breath alcohol concentration (BrAC) and psychomotor evaluation in a clinical monitored study of alcohol intake in Brazil

Alcohol ◽  
2018 ◽  
Vol 66 ◽  
pp. 15-20 ◽  
Author(s):  
Ana Paula Drummond-Lage ◽  
Rodrigo Gomes de Freitas ◽  
Gabriel Cruz ◽  
Luigi Perillo ◽  
Marco Antonio Paiva ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Blood Alcohol ◽  
Breath Alcohol ◽  
Breath Alcohol Concentration

Comparison of Breath and Blood Alcohol Concentrations in a Controlled Drinking Study

2021 ◽  
Author(s):  
Lindsey Skaggs ◽  
Amy Heizler ◽  
Diane Kalscheur ◽  
Amy Miles ◽  
Heather M Barkholtz
Keyword(s):  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Blood Alcohol ◽  
Average Difference ◽  
Limits Of Agreement ◽  
Flame Ionization ◽  
Breath Alcohol ◽  
Dual Sensor ◽  
Highly Correlated ◽  
Breath Alcohol Concentration

Abstract In this work, 114 volunteers were dosed with 80-proof liquor to produce peak blood- or breath- alcohol concentration of 0.040 to 0.080 g/100mL blood or g/210L breath. This was followed by a 30-minute deprivation period before simultaneous blood and breath samples were collected and the alcohol concentration quantified. Blood alcohol concentration was determined by gas chromatography with flame ionization detection and breath alcohol concentration by a dual-sensor Intox EC/IR II instrument. Paired Student t-tests showed that differences between paired blood and breath alcohol results differed significantly. Results from these two measurement methods are highly correlated and, on average, measured blood alcohol concentration was 11.3% greater than breath alcohol concentration. There were ten instances of breath alcohol concentration being greater than the corresponding blood alcohol concentration, and the average difference between these two values was 0.0059 g/100mL. Agreement plots of coupled blood and breath alcohol concentration revealed a mean bias of 0.00754 g/100mL and 95% limits of agreement at -0.00705 and 0.0221 g/100mL. Once breath alcohol concentration values were truncated to the hundredths place as required by Wisconsin state statute, only three participants had greater breath alcohol concentration than corresponding blood alcohol concentration, with an average difference between these values of 0.008 g/100mL. Agreement plots with truncated breath alcohol concentration values gave a mean bias of 0.0120 g/100mL and 95% limits of agreement at -0.00344 and 0.0275 g/100mL. Data showed that typically, blood samples had greater alcohol concentrations than corresponding breath values. Differences were exacerbated by Wisconsin’s statutory requirement that reported breath alcohol measurements be truncated to the hundredths place whereas blood has no corresponding mandate.

Accuracy and precision of breath-alcohol measurements for a random subject in the postabsorptive state.

1987 ◽  
Vol 33 (2) ◽  
pp. 261-268 ◽  
Author(s):  
G Simpson
Keyword(s):  
Blood Alcohol Concentration ◽  
Alcohol Concentration ◽  
Blood Alcohol ◽  
Biological Variables ◽  
Breath Alcohol ◽  
Accuracy And Precision ◽  
Breath Analyzer ◽  
The Subject ◽  
Experimental Values

Abstract The accuracy of estimates of blood-alcohol concentration based on measurements of breath-alcohol concentration in a randomly selected subject by a random quantitative evidential breath-alcohol analyzer is evaluated with respect to the breath analyzer itself, its calibration, and the biological variables of the subject being tested. There are no suitable experimental data for rigorous determination of the overall accuracy, so I estimate it from the CV of the available data. I find that the uncertainty in these breath-analyzer readings for a random subject in the postabsorptive state is at least +/- 15%, +/- 19%, or +/- 27%, depending on whether +/- 2 CV, the experimental range, or +/- 3 CV, respectively, is used to express the overall uncertainty. Over 90% of this uncertainty is due to biological variables of the subject, and at least 23% of subjects will have their actual blood-alcohol concentration overestimated. Manufacturers' specifications for the accuracy and precision of these instruments are inconsistent with the experimental values reported in the literature and I recommend that an appropriate amount of uncertainty be reflected in the results from these breath analyzers, especially when they are used for law-enforcement purposes.

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