Plasma nitrite reserve and endothelial function in the human forearm circulation

2006 ◽  
Vol 41 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Tienush Rassaf ◽  
Christian Heiss ◽  
Ulrike Hendgen-Cotta ◽  
Jan Balzer ◽  
Simone Matern ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Human Forearm ◽  
Plasma Nitrite ◽  
Forearm Circulation

P169. Plasma nitrite reserve and endothelial function in the human forearm circulation

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 72-73
Author(s):  
Tienush Rassaf ◽  
Christian Heiss ◽  
Jan Balzer ◽  
Ulrike Hendgen-Cotta ◽  
Simone Matern ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Human Forearm ◽  
Plasma Nitrite ◽  
Forearm Circulation

Local tissue factor pathway inhibitor release in the human forearm

2003 ◽  
Vol 89 (03) ◽  
pp. 438-445 ◽  
Author(s):  
Jacobus Burggraaf ◽  
Rik Schoemaker ◽  
Adam Cohen ◽  
Cornelis Kluft ◽  
Stanley Chia ◽  
...  
Keyword(s):  
Substance P ◽  
Sodium Nitroprusside ◽  
Regional Differences ◽  
Systemic Circulation ◽  
Unfractioned Heparin ◽  
Human Forearm ◽  
Tissue Factor Pathway ◽  
Forearm Circulation ◽  
Dose Dependent Increase ◽  
Dose Dependent

SummaryNineteen healthy men received unilateral brachial artery infusions of either unfractioned heparin (0.3-100 IU/min), saline or the endothelium-dependent vasodilators substance P (2-8 pmol/min) and bradykinin (100-1000 pmol/min), and the endothelium-independent vasodilator sodium nitroprusside (2-8 µg/min). Heparin caused a dose-dependent increase in plasma TFPI concentrations in both arms (ANOVA, p <0.0001). Estimated net forearm TFPI release was 7 ± 16, 29 ± 20 and 138 ± 72 ng/100 mL tissue/min during 10, 30 and 100 IU/min of heparin respectively (ANOVA, p <0.0001). Compared to the systemic circulation, the forearm sensitivity to heparin induced TFPI release was 3.6-fold lower (166 ± 67 ng/IU vs. 596 ± 252 ng/IU: t-test, p = 0.004). Substance P, bradykinin and sodium nitroprusside all caused substantial dose-dependent increases in blood flow (ANOVA, p <0.001 for all) without affecting plasma TFPI concentrations. There are important regional differences in endothelial TFPI release, with the forearm circulation being relatively insensitive to heparin.

Plasma angiotensins and human forearm circulation: effects of sympatho‐adrenal activation

1997 ◽  
Vol 159 (2) ◽  
pp. 107-111 ◽  
Author(s):  
T. KAHAN ◽  
M. LINDQVIST ◽  
J. NUSSBERGER ◽  
A. MELCHER ◽  
P. HJEMDAHL
Keyword(s):  
Human Forearm ◽  
Forearm Circulation

Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation

1994 ◽  
Vol 28 (5) ◽  
pp. 691-694 ◽  
Author(s):  
A. J d. Belder ◽  
R. MacAllister ◽  
M. W Radomski ◽  
S. Moncada ◽  
P. J T Vallance
Keyword(s):  
Platelet Activation ◽  
Selective Inhibition ◽  
Human Forearm ◽  
Forearm Circulation
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