Differential effects of interleukin 6 and lipopolysaccharide on teleost B lymphocytes

In this paper we have shown that extensively purified human B lymphocytes respond to IL-4 treatment with a marked production of IL-6. Addition of anti-mu potentiated the effect of IL-4 on IL-6 production. Other cytokines tested like TNF-alpha and-beta, IFN-gamma, IL-1, IL-2, and IL-5 did not induce IL-6 secretion when given to resting B cells. Although B cells generally also produced TNF-alpha and TNF-beta upon stimulation, IL-4 did not induce TNF secretion and seemingly had a specific effect on IL-6 production.

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DIFFERENTIAL EFFECTS OF ACUTE HYPOXIA AND ENDOTOXIN ON THE SECRETION AND EXPRESSION OF BONE MARROW INTERLEUKIN-1 AND INTERLEUKIN-6

Shock ◽

10.1097/00024382-199705000-00003 ◽

1997 ◽

Vol 7 (5) ◽

pp. 324-331 ◽

Cited By ~ 16

Author(s):

Alicia M. Mohr ◽

Jeffrey S. Upperman ◽

Rashmi Taneja ◽

Ming T. Wang ◽

Pranela Rameshwar ◽

...

Keyword(s):

Bone Marrow ◽

Interleukin 6 ◽

Acute Hypoxia ◽

Interleukin 1 ◽

Differential Effects

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Differential effects of proclatic upon activation and differentiation of human B lymphocytes

Journal of Neuroimmunology ◽

10.1016/0165-5728(93)90282-4 ◽

1993 ◽

Vol 47 (1) ◽

pp. 35-40 ◽

Cited By ~ 54

Author(s):

Nitza Lahat ◽

Ariel Miller ◽

Relly Shtiller ◽

Ellias Touby

Keyword(s):

B Lymphocytes ◽

Differential Effects

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Transmembrane BAFF from rheumatoid synoviocytes requires interleukin-6 to induce the expression of recombination-activating gene in B lymphocytes

Arthritis & Rheumatism ◽

10.1002/art.24498 ◽

2009 ◽

Vol 60 (5) ◽

pp. 1261-1271 ◽

Cited By ~ 19

Author(s):

Caroline Rochas ◽

Sophie Hillion ◽

Alain Saraux ◽

Rizgar A. Mageed ◽

Pierre Youinou ◽

...

Keyword(s):

B Lymphocytes ◽

Interleukin 6 ◽

Recombination Activating Gene

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Peripheral expression of RAG in human B lymphocytes in normal and pathological conditions is dependent on interleukin-6

Autoimmunity Reviews ◽

10.1016/j.autrev.2007.01.002 ◽

2007 ◽

Vol 6 (6) ◽

pp. 415-420 ◽

Cited By ~ 12

Author(s):

Sophie Hillion ◽

Pierre Youinou ◽

Christophe Jamin

Keyword(s):

B Lymphocytes ◽

Interleukin 6 ◽

Pathological Conditions

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Interleukin-6 Promotes Anti-OspA Borreliacidal Antibody Production In Vitro

Clinical and Vaccine Immunology ◽

10.1128/cvi.13.1.19-25.2006 ◽

2006 ◽

Vol 13 (1) ◽

pp. 19-25 ◽

Cited By ~ 4

Author(s):

Erik L. Munson ◽

Dean T. Nardelli ◽

K. H. Kevin Luk ◽

Monica C. Remington ◽

Steven M. Callister ◽

...

Keyword(s):

Lymph Node ◽

B Lymphocytes ◽

Antibody Production ◽

Interleukin 6 ◽

In Vitro Assay ◽

Vitro Assay ◽

Lymph Node Cells ◽

In Vitro Treatment

ABSTRACT Determination of the immunological mediators responsible for promoting the production of borreliacidal antibody may facilitate the development of an improved borreliosis vaccine for human and veterinary use. Previously, we developed an in vitro assay to determine if borreliacidal antibody production could be augmented by treatment with different cytokines. In this study, in vitro treatment of lymph node cells producing borreliacidal antibody with recombinant interleukin-6 (rIL-6) resulted in a fourfold enhancement of anti-OspA borreliacidal antibody. Moreover, rIL-6 enhanced Western immunoblot titers and increased the number of B lymphocytes. In contrast, treatment of anti-OspA borreliacidal antibody-producing cells with anti-IL-6 resulted in a fourfold reduction in borreliacidal activity. Treatment with anti-IL-6 also inhibited enhanced borreliacidal antibody production induced by anti-gamma interferon. These data suggest that IL-6 plays a significant role in the production of anti-OspA borreliacidal antibodies.

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