Mo1386 Comparative Effectiveness of Metal Versus Plastic Stents for Preoperative Biliary Drainage in Resectable and Borderline Resectable Distal Malignant Biliary Obstruction: a Systematic Review and Meta-Analysis

2015 ◽  
Vol 81 (5) ◽  
pp. AB402
Author(s):  
Tarun Rustagi ◽  
Thomas Mccarty
Keyword(s):  
Systematic Review ◽  
Biliary Drainage ◽  
Comparative Effectiveness ◽  
Biliary Obstruction ◽  
Meta Analysis ◽  
Preoperative Biliary Drainage ◽  
Malignant Biliary Obstruction ◽  
Plastic Stents ◽  
Borderline Resectable ◽  
Distal Malignant Biliary Obstruction

Su1222 WHICH TECHNIQUE IS BETTER: EUS VS ERCP GUIDED BILIARY DRAINAGE FOR DISTAL MALIGNANT BILIARY OBSTRUCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS

2019 ◽  
Vol 89 (6) ◽  
pp. AB322-AB323
Author(s):  
Viveksandeep Thoguluva Chandrasekar ◽  
Ramprasad Jegadeesan ◽  
Seemeen Hassan ◽  
Muhammad Aziz ◽  
Abhiram Duvvuri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Biliary Drainage ◽  
Biliary Obstruction ◽  
Meta Analysis ◽  
Malignant Biliary Obstruction ◽  
Distal Malignant Biliary Obstruction

scholarly journals Endoscopic ultrasound-guided biliary drainage for distal malignant obstruction: a systematic review and meta-analysis of randomized trials

2019 ◽  
Vol 07 (11) ◽  
pp. E1563-E1573 ◽  
Author(s):  
Corey S. Miller ◽  
Alan N. Barkun ◽  
Myriam Martel ◽  
Yen-I Chen
Keyword(s):  
Biliary Drainage ◽  
Biliary Obstruction ◽  
Randomized Trials ◽  
Clinical Success ◽  
Meta Analysis ◽  
Malignant Biliary Obstruction ◽  
First Line ◽  
First Line Therapy ◽  
Catheter Dysfunction ◽  
Distal Malignant Biliary Obstruction

Abstract Background and study aims Endoscopic ultrasound (EUS)-guided biliary drainage (BD) is increasingly used for distal malignant biliary obstruction, yet its safety and efficacy compared to endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic biliary drainage (PTBD) remain unclear. We performed a meta-analysis to improve our understanding of the role of EUS-BD in this patient population. Methods We searched Embase, MEDLINE, CENTRAL, and ISI Web of Knowledge through September 2018 for randomized controlled trials (RCTs) comparing EUS-BD to ERCP-BD or PTBD as treatment of distal malignant biliary obstruction. Risk ratios (RRs) with 95 % confidence intervals (CIs) were combined using random effects models. The primary outcome was risk of stent/catheter dysfunction requiring reintervention. Results Of six trials identified, three (n = 222) compared EUS-BD to ERCP-BD for first-line therapy; three others (n = 132) evaluated EUS-BD versus PTBD after failed ERCP-BD. EUS-BD was associated with a decreased risk of stent/catheter dysfunction overall (RR, 0.39; 95 %CI 0.27 – 0.57) and in planned subgroup analysis when compared to ERCP (RR, 0.41; 95 %CI 0.23 – 0.74) or PTBD (RR, 0.37, 95 %CI 0.22 – 0.61). Compared to ERCP, EUS was associated with a decreased risk of post-procedure pancreatitis (RR, 0.12; 95 %CI 0.01 – 0.97). No differences were noted in technical or clinical success. Conclusions In a meta-analysis of randomized trials comparing EUS-BD to conventional biliary drainage modalities, no difference in technical or clinical success was observed. Importantly, EUS-BD was associated with decreased risks of stent/catheter dysfunction when compared to both PTBD and ERCP, and decreased post-procedure pancreatitis when compared to ERCP, suggesting the potential role for EUS-BD as an alternative first-line therapy in distal malignant biliary obstruction.

Sign in / Sign up

Export Citation Format

Share Document