The responses of harmful dinoflagellate Karenia mikimotoi to simulated ocean acidification at the transcriptional level

Harmful Algae ◽  
2022 ◽  
Vol 111 ◽  
pp. 102167
Author(s):  
Jiazhu Zhang ◽  
Qiongying Yang ◽  
Qianlou Liu ◽  
Shuqi Liu ◽  
Yue Zhu ◽  
...  
Keyword(s):  
Ocean Acidification ◽  
Transcriptional Level ◽  
Karenia Mikimotoi ◽  
Harmful Dinoflagellate

Effects of ocean acidification and phosphate limitation on physiology and toxicity of the dinoflagellate Karenia mikimotoi

Harmful Algae ◽  
2019 ◽  
Vol 87 ◽  
pp. 101621 ◽  
Author(s):  
Hong Wang ◽  
Xiaoqin Niu ◽  
Xinqian Feng ◽  
Rodrigo J. Gonçalves ◽  
Wanchun Guan
Keyword(s):  
Ocean Acidification ◽  
Phosphate Limitation ◽  
Karenia Mikimotoi

scholarly journals RNA Sequencing Revealed Numerous Polyketide Synthase Genes in the Harmful Dinoflagellate Karenia mikimotoi

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142731 ◽  
Author(s):  
Kei Kimura ◽  
Shujiro Okuda ◽  
Kei Nakayama ◽  
Tomoyuki Shikata ◽  
Fumio Takahashi ◽  
...  
Keyword(s):  
Rna Sequencing ◽  
Polyketide Synthase ◽  
Karenia Mikimotoi ◽  
Harmful Dinoflagellate

scholarly journals First record of red tide due to the harmful dinoflagellate Karenia mikimotoi in Hakodate Bay, southern Hokkaido, in autumn 2015

2016 ◽  
Vol 82 (6) ◽  
pp. 934-938 ◽  
Author(s):  
HIROSHI SHIMADA ◽  
MAKOTO KANAMORI ◽  
HIDETSUGU YOSHIDA ◽  
ICHIRO IMAI
Keyword(s):  
Red Tide ◽  
First Record ◽  
Karenia Mikimotoi ◽  
Harmful Dinoflagellate

Will harmful dinoflagellate Karenia mikimotoi grow phagotrophically?

2011 ◽  
Vol 29 (4) ◽  
pp. 849-859 ◽  
Author(s):  
Qingchun Zhang ◽  
Rencheng Yu ◽  
Jingjing Song ◽  
Tian Yan ◽  
Yunfeng Wang ◽  
...  
Keyword(s):  
Karenia Mikimotoi ◽  
Harmful Dinoflagellate

Endotoxin-Induced Tissue Factor in Human Monocytes is Dependent upon Protein Kinase C Activation

1993 ◽  
Vol 70 (05) ◽  
pp. 800-806 ◽  
Author(s):  
C Ternisien ◽  
M Ramani ◽  
V Ollivier ◽  
F Khechai ◽  
T Vu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tissue Factor ◽  
Factor Ix ◽  
Transcriptional Level ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Human Monocytes ◽  
Kinase C ◽  
Pkc Activation

SummaryTissue factor (TF) is a transmembrane receptor which, in association with factors VII and Vila, activates factor IX and X, thereby activating the coagulation protease cascades. In response to bacterial lipopolysaccharide (LPS) monocytes transcribe, synthesize and express TF on their surface. We investigated whether LPS-induced TF in human monocytes is mediated by protein kinase C (PKC) activation. The PKC agonists phorbol 12- myristate 13-acetate (PMA) and phorbol 12, 13 dibutyrate (PdBu) were both potent inducers of TF in human monocytes, whereas 4 alpha-12, 13 didecanoate (4 a-Pdd) had no such effect. Both LPS- and PMA-induced TF activity were inhibited, in a concentration dependent manner, by three different PKC inhibitors: H7, staurosporine and calphostin C. TF antigen determination confirmed that LPS-induced cell-surface TF protein levels decreased in parallel to TF functional activity under staurosporine treatment. Moreover, Northern blot analysis of total RNA from LPS- or PMA-stimulated monocytes showed a concentration-dependent decrease in TF mRNA levels in response to H7 and staurosporine. The decay rate of LPS-induced TF mRNA evaluated after the arrest of transcription by actinomycin D was not affected by the addition of staurosporine, suggesting that its inhibitory effect occurred at a transcriptional level. We conclude that LPS-induced production of TF and its mRNA by human monocytes are dependent on PKC activation.

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