Oral administration of branched-chain amino acids activates the mTOR signal in cirrhotic rat liver

2005 ◽  
Vol 33 (1) ◽  
pp. 27-32 ◽  
Author(s):  
T MATSUMURA ◽  
Y MORINAGA ◽  
S FUJITANI ◽  
K TAKEHANA ◽  
S NISHITANI ◽  
...  
Keyword(s):  
Amino Acids ◽  
Oral Administration ◽  
Rat Liver ◽  
Branched Chain Amino Acids ◽  
Branched Chain

Oral administration of branched chain amino acids improves virus-induced glucose intolerance in mice

2000 ◽  
Vol 398 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Toshihiro Utsugi ◽  
Akihiro Yoshida ◽  
Tsugiyasu Kanda ◽  
Isao Kobayashi ◽  
Masahiko Kurabayashi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Oral Administration ◽  
Glucose Intolerance ◽  
Branched Chain Amino Acids ◽  
Branched Chain

scholarly journals Developmental changes in rat liver branched-chain 2-oxo acid dehydrogenase

1982 ◽  
Vol 204 (2) ◽  
pp. 487-492 ◽  
Author(s):  
E E May ◽  
M E May ◽  
R P Aftring ◽  
M G Buse
Keyword(s):  
Amino Acids ◽  
Rat Liver ◽  
Maternal Diabetes ◽  
Perinatal Period ◽  
Branched Chain Amino Acids ◽  
Developmental Changes ◽  
Acid Dehydrogenase ◽  
Period 2 ◽  
Liver Homogenates ◽  
Branched Chain

Branched-chain 2-oxo acid dehydrogenase catalyses the first irreversible step in the degradation of the branched-chain amino acids leucine, isoleucine and valine. With specifically labelled 4-methyl-2-oxo[1-14C]pentanoate as substrate, the enzyme's activity was measured in rat liver homogenates. Activity (per g wet wL of liver or per mg of protein) increased most rapidly during the perinatal period (2 days before to 1 day after birth), reaching approximately adult values by the time of weaning. The apparent Vmax, of the enzyme increased with age, but its Km appeared unchanged. The data suggest that hepatic branched-chain 2-oxo acid dehydrogenase is induced or activated during the perinatal period. The enzyme's activity at birth was unaffected by maternal diabetes, or by treating the mother with pharmacological doses of corticosterone or 3,3',5-tri-iodothyronine, during the last 5 days of pregnancy.

Effect of the Oral Administration of Branched Chain Amino Acids on Hepatic Encephalopathy in the Rat

Hepatology ◽  
1984 ◽  
Vol 4 (2) ◽  
pp. 288-294 ◽  
Author(s):  
Christian Beaubernard ◽  
Marie-Louise Delorme ◽  
Pierre Opolon ◽  
Mlchele Boschat ◽  
Joelle Morin ◽  
...  
Keyword(s):  
Amino Acids ◽  
Hepatic Encephalopathy ◽  
Oral Administration ◽  
Branched Chain Amino Acids ◽  
Branched Chain
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