Objective: To determine correlation of echo-doppler optimization of atrioventricular delay in cardiac resynchronization therapy with left ventricular invasive hemodynamics optimization.
Methods: Intervention prospective study.
Result: In 25 patients (48% female, mean age 6.1±10.6, had diagnosis heart failure NYHA IIIV with LVEF= 26.9±5.7%, sinus rhythm, QRS wide is 170±22.1 ms) who underwent CRT. AVsense optimization were determined by invasive LV dP/dtmax, and the Doppler echocardiographic methods evaluated were the velocity–time integral (VTI) of the transmitralflow (EA VTI), the VTI of the LV outflow tractor aorta (LV VTI). The result are 117.8±15.2ms; 117.2±14.5ms and 120.8 ± 12.8ms, prospectively. The optimal AVsense delay with the EA VTI method was most concordant with LV dP/dtmax(r=0,953), LV VTI was less concordant (r=0.568). The result of AVpace optimization by three methods are 159.6±17.9ms; 159±16.2ms và 165±13.8ms, prospectively. The optimal AVpace delay with the EA VTI method was most concordant with LV dP/dtmax (r=0.964), LV VTI was less concordant (r=0.734).
Conclusions: Comparing with invasive LV dP/dtmax, measurement of the maximal VTI of mitral inflow is more concordant than LV VTI in AVsense and AVpace optimization. If we optimize AVsense and AVpace, for replacing invasive LV dP/dtmax, EA VTI method was better option.
Key words: Dyssychronization, CRT, optimization, dP/dtmax
Feasibility of a novel atrioventricular delay optimization method using transmitral and pulmonary venous flow in patients with sequential ventricular pacing or cardiac resynchronization therapy
