FGFR1 translocation with concurrent myeloproliferative neoplasm, systemic mastocytosis, and lymphoblastic lymphoma: a case report

2018 ◽  
Vol 74 ◽  
pp. 114-121 ◽  
Author(s):  
Koping Chang ◽  
Jia-Hau Liu ◽  
Shan-Chi Yu ◽  
Chung-Wu Lin
Keyword(s):  
Case Report ◽  
Systemic Mastocytosis ◽  
Myeloproliferative Neoplasm ◽  
Lymphoblastic Lymphoma

scholarly journals Indolent systemic mastocytosis limited to the bone: a case report and review of the literature

2013 ◽  
Vol 131 (3) ◽  
pp. 198-204 ◽  
Author(s):  
Pedro Pinto-Lopes ◽  
Francisco Adao Fonseca ◽  
Roberto Silva ◽  
Pedro von Hafe ◽  
Elsa Fonseca
Keyword(s):  
Case Report ◽  
Systemic Mastocytosis ◽  
Wide Spectrum ◽  
Myeloproliferative Neoplasm ◽  
Caucasian Woman ◽  
Review Of The Literature ◽  
Poor Overall Survival ◽  
Skeletal Changes ◽  
Indolent Disease ◽  
Indolent Systemic Mastocytosis

CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emergency Department because of complaints of low back pain. Before this, she had consulted an orthopedist and had undergone some imaging examinations, namely a bone scan that revealed a “superscan” pattern. Due to her pain complaints and these test results, the patient was admitted to the Department of Internal Medicine. After undergoing several analytical tests and some additional imaging examinations to rule out some important differential diagnoses, she then underwent bone marrow biopsy, which made it possible to identify indolent systemic mastocytosis. CONCLUSION Systemic mastocytosis is a rare entity that is difficult to diagnose. Its symptoms are often unspecific and frequently ignored. Skeletal changes may be the first and only manifestation of the disease and in some cases, like this one, the diagnosis is made only after histological examination. The key point for the diagnosis is to contemplate the possibility of systemic mastocytosis.

Selective Dysmegakaryocytopoiesis Secondary to Chemotherapy in a Dog with Lymphoblastic Lymphoma: A Case Report

2018 ◽  
Vol 02 (01) ◽  
Author(s):  
Margaret L Musser ◽  
Kayden E Toone ◽  
Erika P Berger ◽  
Austin K Viall ◽  
Leslie E Fox ◽  
...  
Keyword(s):  
Case Report ◽  
Lymphoblastic Lymphoma

scholarly journals Management of myelofibrosis during pregnancy: A case report

2015 ◽  
Vol 72 (4) ◽  
pp. 383-385 ◽  
Author(s):  
Radmila Zivkovic ◽  
Olivera Markovic ◽  
Dragomir Marisavljevic ◽  
Tatjana Terzic ◽  
Ljiljana Tukic
Keyword(s):  
Case Report ◽  
Myeloproliferative Neoplasm ◽  
Primary Myelofibrosis ◽  
Normal Pregnancy ◽  
Hematologic Malignancies ◽  
Low Molecular Weight ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Pregnancy And Delivery ◽  
Normal Baby

Introduction. Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm that occurs most commonly in the decade six of life and it is very rare in the young persons. Case report. We reported a 28-year-old female patient with primary myelofibrosis who had a normal pregnancy and delivery in the week 40 of pregnancy without any complications. Two years before the diagnosis of PMF she had normal pregnancy. The patient was treated with interferon-alpha and low dose aspirin during the whole pregnancy and with low-molecular-weight heparin a week before delivery and 6 weeks after. The patient had no complications during pregnancy. She delivered in term with healthy, normal baby weight. Conclusion. Decision about treatment strategy of pregnancy associated hematologic malignancies should be made for each patient individually.

scholarly journals Splanchnic venous thrombosis driven by a constitutively activated JAK2 V617F philadelphia-negative myeloproliferative neoplasm: a case report

2015 ◽  
Vol 14 (4) ◽  
pp. 1069
Author(s):  
M Waiswa ◽  
E Seremba ◽  
P Ocama ◽  
H Ddungu ◽  
K Opio ◽  
...  
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Myeloproliferative Neoplasm ◽  
Jak2 V617f

scholarly journals T-lymphoblastic lymphoma/leukemia without clonal TCR gene rearrangements: case report and literature review

2021 ◽  
Vol 10 (3) ◽  
pp. 1603-1608
Author(s):  
Jiuju Wang ◽  
Shanshan Jiang ◽  
Qiaojiajie Zhao ◽  
Xucang Wei ◽  
Wensheng Li
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lymphoblastic Lymphoma ◽  
Gene Rearrangements ◽  
T Lymphoblastic Lymphoma

Pediatric Philadelphia chromosome‐positive B‐lymphoblastic lymphoma with testicular relapse: A case report

2021 ◽  
Author(s):  
Ryo Maemura ◽  
Hirotoshi Sakaguchi ◽  
Nao Yoshida ◽  
Daiki Yamashita ◽  
Daichi Sajiki ◽  
...  
Keyword(s):  
Case Report ◽  
Philadelphia Chromosome ◽  
Lymphoblastic Lymphoma ◽  
B Lymphoblastic Lymphoma ◽  
Philadelphia Chromosome Positive

scholarly journals MDS with 5q deletion and rare cKIT positive mastocytosis: a diagnostic and therapeutic challenge

2019 ◽  
Vol 12 (4) ◽  
pp. e227768
Author(s):  
Daniel Steven Sanders ◽  
Thomas Fennell ◽  
Mohammad Muhsin Chisti
Keyword(s):  
Bone Marrow ◽  
Mast Cell ◽  
Case Report ◽  
Systemic Mastocytosis ◽  
Molecular Testing ◽  
Bone Marrow Biopsies ◽  
Haematological Response ◽  
Clonal Origin ◽  
Mast Cell Population ◽  
5Q Deletion

A patient with a diagnosis of myelodysplastic syndrome (MDS) with isolated 5q deletion underwent repeat bone marrow biopsy to assess haematological response after 6 months of initial lenalidomide therapy. Subsequent bone marrow biopsies revealed persistent MDS with del(5q) in addition to a small atypical mast cell population with >25% of mast cells with spindle-shaped morphology and immunohistochemistry characteristics consistent with mastocytosis. Molecular testing on the bone marrow was positive for cKIT D816V and the patient was diagnosed with systemic mastocytosis (SM) with an associated haematological neoplasm. MDS with SM is well known to be associated; however, to the best of our knowledge, only one prior case report identifies MDS with del(5q) and associated cKIT D816V positive mastocytosis. While the exact clonal origin of both chromosomal aberrations is unclear, this case illustrates the therapeutic efficacy of lenalidomide in a patient with MDS with del(5q) and rarely associated cKIT positive SM.

Novel Detection of CALR-Mutated Cells in Myeloproliferative Neoplasm-Related Glomerulopathy With Interstitial Extramedullary Hematopoiesis: A Case Report

2019 ◽  
Vol 74 (6) ◽  
pp. 844-848
Author(s):  
Keisuke Maruyama ◽  
Naoki Nakagawa ◽  
Ayana Suzuki ◽  
Maki Kabara ◽  
Motoki Matsuki ◽  
...  
Keyword(s):  
Case Report ◽  
Myeloproliferative Neoplasm ◽  
Extramedullary Hematopoiesis

E035 Sacral fracture in systemic mastocytosis: a case report

Rheumatology ◽  
2019 ◽  
Vol 58 (Supplement_3) ◽  
Author(s):  
Siwalik Banerjee ◽  
Shanmugam Saravana
Keyword(s):  
Case Report ◽  
Systemic Mastocytosis ◽  
Sacral Fracture
Sign in / Sign up

Export Citation Format

Share Document