Synthesis, crystal structure and characterization of three novel copper complexes of Levofloxacin. Study of their DNA binding properties and biological activities

2014 ◽  
Vol 423 ◽  
pp. 207-218 ◽  
Author(s):  
Anastasia Galani ◽  
Eleni K. Efthimiadou ◽  
George Mitrikas ◽  
Yiannis Sanakis ◽  
Vassilis Psycharis ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Copper Complexes ◽  
Biological Activities ◽  
Binding Properties ◽  
Dna Binding Properties

The crystal structure of a natural DNA polymerase complexed with mirror DNA

2020 ◽  
Vol 56 (14) ◽  
pp. 2186-2189
Author(s):  
Jinsu An ◽  
Jaewoo Choi ◽  
Dohyeon Hwang ◽  
Jihyun Park ◽  
Charles W. Pemble ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Dna Polymerase ◽  
Binding Properties ◽  
Dna Binding Properties

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered.

Synthesis, Crystal Structure, DNA-binding Properties and Antioxidant Activities of a Lutetium(III) Complex with the Bis(N-salicylidene)-3- oxapentane-1,5-diamine Ligand

2013 ◽  
Vol 68 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Guolong Pan ◽  
Yuchen Bai ◽  
Hua Wang ◽  
Jin Kong ◽  
Furong Shi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Binding Mode ◽  
Binding Properties ◽  
Metal Centers ◽  
Spectrophotometric Methods ◽  
Dna Binding Properties

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its lutetium(III) complex, with composition Lu2(L)2(NO3)2, were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Lu(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Lu(III) metal centers are bridged by two phenoxo oxygen atoms. The DNA-binding properties of the Lu(III) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Lu(III) complex binds to DNA via a groove binding mode. Additionally, the antioxidant activity of the Lu(III) complex was determined by the superoxide and hydroxyl radical scavenging methods in vitro, which indicate that it is a scavenger for OH· and O-· 2 radicals.

Sign in / Sign up

Export Citation Format

Share Document